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Compound Detail

CHEMBL308295

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CCCN(CCCCCCN1CCC[C@@H]1Cc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1

Basic Information

ChEMBL ID CHEMBL308295
Phase Preclinical
Structure Type MOL
InChI Key NGGFFSQKRFAGBP-XMMPIXPASA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

470.6
MW (Da)
5.03
ALogP
6
HBA
4
HBD
87.4
PSA (Ų)
0.23
QED
1
Ro5 Violations
14
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H42N2O4
MW 470.65
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness -0.35

Activity Summary

Ki 4 meas. best 8.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL339
Ki 8.49 8.49 3.2 1
D(1A) dopamine receptor
CHEMBL265
Ki 7.73 7.73 18.6 1
Adenosine receptor A2b
CHEMBL2592
Ki 6.52 6.52 302.0 1
Adrenergic receptor alpha-1
CHEMBL2094251
Ki 6.41 6.41 389.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00413-N Canis familiaris 4
- 10.1016/0960-894X(95)00413-N Rattus norvegicus 2
- 10.1016/0960-894X(95)00413-N D(1A) dopamine receptor 1
- 10.1016/0960-894X(95)00413-N D(2) dopamine receptor 1
- 10.1016/0960-894X(95)00413-N Adrenergic receptor alpha-1 1
- 10.1016/0960-894X(95)00413-N Adenosine receptor A2b 1
- 10.1016/0960-894X(95)00413-N Beta-1 adrenergic receptor 1
- 10.1016/0960-894X(95)00413-N Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine