Adenosine receptor A2b · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P29276. Use UniProt P29276 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P29276 as the stable identity anchor, then attach disease evidence before program review.
Adenosine receptor A2b
Review this target as Adenosine receptor A2b, mapped to UniProt P29276. Sequence length is 332 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adenosine receptor A2b as ChEMBL target CHEMBL2592, mapped to UniProt P29276. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Adenosine receptor A2b |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P29276 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Adenosine receptor A2b |
| UniProt Accession | P29276 |
| Component Type | Protein |
| Sequence Length | 332 aa |
Adenosine receptor A2b
Review this target as Adenosine receptor A2b, mapped to UniProt P29276. Sequence length is 332 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4205635 | 9.74 | Ki | 0.18 | Preclinical |
| CHEMBL456125 | 9.33 | Kd | 0.4677 | Preclinical |
| CHEMBL513681 | 8.66 | Kd | 2.188 | Preclinical |
| CHEMBL273807 | 7.89 | Ki | 12.8 | Preclinical |
| CHEMBL10347 | 7.86 | Kd | 13.8 | Preclinical |
| CHEMBL588 | 7.45 | Ki | 35.48 | Approved |
| CHEMBL310997 | 7.24 | Ki | 57.54 | Preclinical |
| CHEMBL2181976 | 6.79 | Ki | 163.0 | Preclinical |
| CHEMBL10873 | 6.76 | Ki | 174.0 | Preclinical |
| CHEMBL45244 | 6.75 | Ki | 177.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 14 | 9 | 6.5 |
| cell-based format | 8 | 20 | 5.9 |
| assay format | 2 | 1 | 7.0 |
| cell membrane format | 2 | 0 | — |
| organism-based format | 1 | 2 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 13 | 3 | 8.6 |
| assay format | 6 | 0 | — |
| cell-based format | 5 | 22 | 6.0 |