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Compound Detail

CHEMBL310997

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Oc1ccc(C[C@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O

Basic Information

ChEMBL ID CHEMBL310997
Phase Preclinical
Structure Type MOL
InChI Key VQJOREUOQIWUDM-DNQXCXABSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

468.6
MW (Da)
4.78
ALogP
6
HBA
4
HBD
87.4
PSA (Ų)
0.28
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H40N2O4
MW 468.64
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness 0.05

Activity Summary

Ki 4 meas. best 8.21

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL339
Ki 8.21 8.21 6.2 1
D(1A) dopamine receptor
CHEMBL265
Ki 8.19 8.19 6.5 1
Adrenergic receptor alpha-1
CHEMBL2094251
Ki 7.25 7.25 56.2 1
Adenosine receptor A2b
CHEMBL2592
Ki 7.24 7.24 57.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00413-N Canis familiaris 4
- 10.1016/0960-894X(95)00413-N Rattus norvegicus 2
- 10.1016/0960-894X(95)00413-N D(1A) dopamine receptor 1
- 10.1016/0960-894X(95)00413-N D(2) dopamine receptor 1
- 10.1016/0960-894X(95)00413-N Adrenergic receptor alpha-1 1
- 10.1016/0960-894X(95)00413-N Adenosine receptor A2b 1
- 10.1016/0960-894X(95)00413-N Beta-1 adrenergic receptor 1
- 10.1016/0960-894X(95)00413-N Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine