Assay Detail
Binding
CHEMBL668244
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Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N,N-6-bis-[2-(3,4-dihydroxybenzyl)pyrrolidinyl]hexane, a potent, selective, orally active dopamine analog with hypotensive and diuretic activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.15 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 8.91 |
| CHEMBL310997 | — | — | 1 | 8.19 |
| CHEMBL80369 | — | — | 1 | 8.10 |
| CHEMBL308295 | — | — | 1 | 7.73 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.51 |
| CHEMBL80974 | — | — | 1 | 6.24 |
| CHEMBL80686 | — | — | 1 | 6.21 |
| CHEMBL15564 | — | — | 1 | 5.33 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL310997 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL80369 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL308295 | — | Ki | = | 18.62 | nM | 7.73 |
| CHEMBL59 | DOPAMINE | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL80974 | — | Ki | = | 575.44 | nM | 6.24 |
| CHEMBL80686 | — | Ki | = | 616.6 | nM | 6.21 |
| CHEMBL15564 | — | Ki | = | 4677.35 | nM | 5.33 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 316227.77 | nM | - |