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Evidence Snapshot

D(1A) dopamine receptor

CHEMBL265 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:19:58Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL265
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats D(1A) dopamine receptor as ChEMBL target CHEMBL265, mapped to UniProt P18901. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
D(1A) dopamine receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL265
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P18901
D(1A) dopamine receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why D(1A) dopamine receptor matters

As of 2026-09-13

D(1A) dopamine receptor is reviewed as D(1A) dopamine receptor (UniProt P18901); the current evidence base includes 24 approved drugs, 1241 compounds, and 284 assays, with lead potency reaching pChEMBL 10.1.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 24 approved drugs, 1241 compounds, and 284 assays for this target. The dominant activity type is KI. CHEMBL441618 is the current potency anchor at pChEMBL 10.1.

Use CHEMBL441618 as the tractability anchor when discussing potency (pChEMBL 10.1).

Activity source · ChEMBL 36 via Core Engine
24 approved pChEMBL 10.1
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why D(1A) dopamine receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P18901, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1241
Total Compounds
284
Total Assays
24
Approved Drugs
IC50: 450.0, KI: 982.0, EC50: 67.0, KD: 4.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL441618
 10.1 Ki —
No preferred name
CHEMBL3763331
 10.0 Ki —
No preferred name
CHEMBL62
 9.9 Ki —
No preferred name
CHEMBL13632
 9.6 Ki —
No preferred name
CHEMBL1185
 9.5 Kd Approved

Approved Drugs

Structure Compound First Approval
ARIPIPRAZOLE
CHEMBL1112
 2002
APOMORPHINE
CHEMBL53
 2001
APOMORPHINE HYDROCHLORIDE
CHEMBL3187985
 2001
ZOLMITRIPTAN
CHEMBL1185
 1997
FENOLDOPAM
CHEMBL588
 1997
SERTINDOLE
CHEMBL12713
 1996
OLANZAPINE
CHEMBL715
 1996
RISPERIDONE
CHEMBL85
 1993
CLOZAPINE
CHEMBL42
 1989
DOPAMINE
CHEMBL59
 1974
HALOPERIDOL
CHEMBL54
 1967
THIORIDAZINE
CHEMBL479
 1962
CHLORPROMAZINE
CHEMBL71
 1957
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:19:58Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL265