Compound Detail
CHEMBL3763331
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Basic Information
| ChEMBL ID | CHEMBL3763331 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWVQWEATHIBBPB-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3765893 |
| Active Moiety | CHEMBL3765893 |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
450.5
MW (Da)
3.89
ALogP
4
HBA
1
HBD
48.5
PSA (Ų)
0.53
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 10.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(1A) dopamine receptor CHEMBL265 | Ki | 10.01 | 10.01 | 0.1 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 9.89 | 9.89 | 0.1 | 1 |
| D(2) dopamine receptor CHEMBL339 | Ki | 7.58 | 7.58 | 26.6 | 1 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | Ki | 5.66 | 5.66 | 2200.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | Ki | 5.65 | 5.65 | 2220.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(1A) dopamine receptor | Ki | = | 0.0983 | nM | 10.01 | Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubate... | 26820556 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 0.13 | nM | 9.89 | Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Sprague-Dawley rat brain co... | 26820556 |
| D(2) dopamine receptor | Ki | = | 26.6 | nM | 7.58 | Displacement of [3H]spiperone from dopamine D2 receptor in rat striatum incubate... | 26820556 |
| Adrenergic receptor alpha-2 | Ki | = | 2200.0 | nM | 5.66 | Displacement of [3H]yohimbine from alpha2 adrenergic receptor in rat brain corte... | 26820556 |
| Adrenergic receptor alpha-1 | Ki | = | 2220.0 | nM | 5.65 | Displacement of [3H]prazosin from alpha1 adrenergic receptor in rat brain cortex... | 26820556 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26820556 | 10.1016/j.ejmech.2016.01.021 | Mus musculus | 7 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | Rattus norvegicus | 2 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | 5-hydroxytryptamine receptor 1A | 1 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | 5-hydroxytryptamine receptor 2A | 1 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | 5-hydroxytryptamine receptor 2C | 1 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | Adrenergic receptor alpha-1 | 1 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | Adrenergic receptor alpha-2 | 1 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | D(1A) dopamine receptor | 1 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | D(2) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine