Assay Detail
Binding
CHEMBL3767685
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Displacement of [3H]yohimbine from alpha2 adrenergic receptor in rat brain cortex incubated for 30 mins by liquid scintillation counting analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.17 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764575 | — | — | 1 | 6.77 |
| CHEMBL3763812 | — | — | 1 | 6.66 |
| CHEMBL3763474 | — | — | 1 | 6.22 |
| CHEMBL104593 | — | — | 1 | 6.08 |
| CHEMBL3763714 | — | — | 1 | 5.95 |
| CHEMBL3764420 | — | — | 1 | 5.88 |
| CHEMBL3763331 | — | — | 1 | 5.66 |
| CHEMBL3764539 | — | — | 1 | - |
| CHEMBL3765231 | — | — | 1 | - |
| CHEMBL3765362 | — | — | 1 | - |
| CHEMBL3765471 | — | — | 1 | - |
| CHEMBL3764177 | — | — | 1 | - |
| CHEMBL3764390 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764575 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL3763812 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL3763474 | — | Ki | = | 604.0 | nM | 6.22 |
| CHEMBL104593 | — | Ki | = | 828.0 | nM | 6.08 |
| CHEMBL3763714 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL3764420 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL3763331 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3764539 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765231 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765362 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765471 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764177 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764390 | — | Ki | > | 10000.0 | nM | - |