5-hydroxytryptamine receptor 1A · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P19327. Use UniProt P19327 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P19327 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 1A
Review this target as 5-hydroxytryptamine receptor 1A, mapped to UniProt P19327. Sequence length is 422 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 1A as ChEMBL target CHEMBL273, mapped to UniProt P19327. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 5-hydroxytryptamine receptor 1A |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P19327 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 1A |
| UniProt Accession | P19327 |
| Component Type | Protein |
| Sequence Length | 422 aa |
5-hydroxytryptamine receptor 1A
Review this target as 5-hydroxytryptamine receptor 1A, mapped to UniProt P19327. Sequence length is 422 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3884161 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL186423 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3764390 | 10.95 | Ki | 0.0113 | Preclinical |
| CHEMBL2387253 | 10.92 | Ki | 0.012 | Preclinical |
| CHEMBL2112779 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL3885003 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL189384 | 10.68 | Ki | 0.021 | Preclinical |
| CHEMBL83625 | 10.68 | IC50 | 0.021 | Preclinical |
| CHEMBL2112780 | 10.59 | Ki | 0.026 | Preclinical |
| CHEMBL2112778 | 10.55 | Ki | 0.028 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 243 | 1,682 | 7.3 |
| single protein format | 123 | 829 | 7.6 |
| cell membrane format | 101 | 914 | 7.4 |
| assay format | 62 | 986 | 7.3 |
| cell-based format | 19 | 241 | 8.2 |
| organism-based format | 8 | 8 | 8.4 |
| subcellular format | 1 | 38 | 8.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 44 | 10 | 7.2 |
| organism-based format | 24 | 0 | — |
| tissue-based format | 17 | 57 | 7.8 |
| cell membrane format | 14 | 21 | 7.7 |
| cell-based format | 2 | 0 | — |