Assay Detail
Binding
CHEMBL3767683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.37 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763331 | — | — | 1 | 7.58 |
| CHEMBL104593 | — | — | 1 | 6.27 |
| CHEMBL3763474 | — | — | 1 | 5.85 |
| CHEMBL3765471 | — | — | 1 | 5.78 |
| CHEMBL3763714 | — | — | 1 | - |
| CHEMBL3764539 | — | — | 1 | - |
| CHEMBL3763812 | — | — | 1 | - |
| CHEMBL3765231 | — | — | 1 | - |
| CHEMBL3765362 | — | — | 1 | - |
| CHEMBL3764575 | — | — | 1 | - |
| CHEMBL3764420 | — | — | 1 | - |
| CHEMBL3764177 | — | — | 1 | - |
| CHEMBL3764390 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763331 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL104593 | — | Ki | = | 537.0 | nM | 6.27 |
| CHEMBL3763474 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL3765471 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL3763714 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764539 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3763812 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765231 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765362 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764575 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764420 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764177 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764390 | — | Ki | > | 10000.0 | nM | - |