Adrenergic receptor alpha-1 · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-13Adrenergic receptor alpha-1 shows approved-linked disease relevance led by hypertension. 5 more disease programs remain visible in the same review block. 5 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P35348. Start with hypertension, then reuse UniProt P35348 as the stable protein anchor across project notes and exports.
Start with hypertension, then reuse UniProt P35348 as the stable protein anchor across project notes and exports.
Adrenergic receptor alpha-1 shows approved-linked disease relevance led by hypertension. 5 more disease programs remain visible in the same review block. 5 linked drugs remain visible in the same block.
Start review with hypertension because it currently carries approved-linked support. Linked drugs include CARVEDILOL, CARVEDILOL PHOSPHATE, DOXAZOSIN MESYLATE, PRAZOSIN HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAlpha-1A adrenergic receptor
Review this target as Adrenergic receptor alpha-1, mapped to UniProt P35348. ChEMBL maps the protein component as Alpha-1A adrenergic receptor. Sequence length is 466 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adrenergic receptor alpha-1 as ChEMBL target CHEMBL2094251, mapped to UniProt P35348. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Adrenergic receptor alpha-1 is the right protein anchor across sources, using UniProt P35348 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hypertension is currently framed as approved-linked support. It currently carries 5 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Adrenergic receptor alpha-1 |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P35348 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-1A adrenergic receptor |
| UniProt Accession | P35348 |
| Component Type | Protein |
| Sequence Length | 466 aa |
Alpha-1A adrenergic receptor
Review this target as Adrenergic receptor alpha-1, mapped to UniProt P35348. ChEMBL maps the protein component as Alpha-1A adrenergic receptor. Sequence length is 466 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Adrenergic receptor alpha-1 shows approved-linked disease relevance led by hypertension. 5 more disease programs remain visible in the same review block.
Start review with hypertension because it currently carries approved-linked support. Linked drugs include CARVEDILOL, CARVEDILOL PHOSPHATE, DOXAZOSIN MESYLATE, PRAZOSIN HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL836 | 10.4 | Kd | 0.03981 | Approved |
| CHEMBL2 | 10.27 | Ki | 0.054 | Approved |
| CHEMBL196961 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL196958 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL198462 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL2 | 9.77 | IC50 | 0.17 | Approved |
| CHEMBL197338 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL371094 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL200315 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL2 | 9.42 | Kd | 0.3802 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 118 | 210 | 7.1 |
| assay format | 31 | 72 | 7.2 |
| tissue-based format | 17 | 68 | 6.6 |
| cell-based format | 8 | 7 | 6.1 |
| cell membrane format | 4 | 22 | 7.2 |
| organism-based format | 1 | 5 | 8.1 |
| single protein format | 1 | 1 | 9.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 18 | 20 | 7.4 |
| tissue-based format | 15 | 17 | 7.3 |
| cell-based format | 3 | 1 | 8.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 1 | 3 | 6.6 |