Assay Detail
Binding
CHEMBL646079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its binding affinity against Alpha-2 adrenergic receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N,N-6-bis-[2-(3,4-dihydroxybenzyl)pyrrolidinyl]hexane, a potent, selective, orally active dopamine analog with hypotensive and diuretic activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.52 | 7.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 7.45 |
| CHEMBL310997 | — | — | 1 | 7.24 |
| CHEMBL308295 | — | — | 1 | 6.52 |
| CHEMBL80974 | — | — | 1 | 6.03 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.01 |
| CHEMBL80686 | — | — | 1 | 5.84 |
| CHEMBL15564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL310997 | — | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL308295 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL80974 | — | Ki | = | 933.25 | nM | 6.03 |
| CHEMBL59 | DOPAMINE | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL80686 | — | Ki | = | 1445.44 | nM | 5.84 |
| CHEMBL15564 | — | Ki | < | 10000.0 | nM | - |