Assay Detail
Binding
CHEMBL669035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 5.65 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 7.55 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 6.82 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.17 |
| CHEMBL1161520 | — | — | 1 | 5.74 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 5.74 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.60 |
| CHEMBL611801 | — | — | 1 | 5.34 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 5.01 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 4.30 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | Kd | = | 28.0 | nM | 7.55 |
| CHEMBL24077 | (R)-SKF-38393 | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL53 | APOMORPHINE | Kd | = | 680.0 | nM | 6.17 |
| CHEMBL1161520 | — | Kd | = | 1818.0 | nM | 5.74 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Kd | = | 1816.0 | nM | 5.74 |
| CHEMBL59 | DOPAMINE | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL611801 | — | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL39 | SEROTONIN | Kd | = | 9690.0 | nM | 5.01 |
| CHEMBL1437 | NOREPINEPHRINE | Kd | = | 50000.0 | nM | 4.30 |
| CHEMBL679 | EPINEPHRINE | Kd | = | 55000.0 | nM | 4.26 |