Assay Detail
Binding
CHEMBL672372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro affinity at wild type Dopamine receptor D2 on C6 (glioma) cell membranes.
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | C6 glioma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 22 | 6.67 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 9.22 |
| CHEMBL227213 | — | — | 2 | 9.21 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 8.10 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 8.05 |
| CHEMBL612083 | — | — | 1 | 8.00 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 7.52 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.70 |
| CHEMBL1160788 | — | — | 1 | 6.68 |
| CHEMBL104141 | — | — | 2 | 6.52 |
| CHEMBL317741 | — | — | 1 | 6.40 |
| CHEMBL301559 | — | — | 1 | 6.40 |
| CHEMBL34095 | — | — | 1 | 6.32 |
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 5.89 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 5.72 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 5.64 |
| CHEMBL1160787 | — | — | 2 | 5.52 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.21 |
| CHEMBL286080 | SKF-38393 | — | 1 | 4.34 |
| CHEMBL1160785 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL227213 | — | Kd | = | 0.62 | nM | 9.21 |
| CHEMBL227213 | — | Kd | = | 0.62 | nM | 9.21 |
| CHEMBL493 | BROMOCRIPTINE | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL612083 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL531 | PERGOLIDE | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL53 | APOMORPHINE | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL1160788 | — | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL104141 | — | Kd | = | 300.0 | nM | 6.52 |
| CHEMBL104141 | — | Kd | = | 300.0 | nM | 6.52 |
| CHEMBL317741 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL301559 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL34095 | — | Kd | = | 480.0 | nM | 6.32 |
| CHEMBL588 | FENOLDOPAM | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL240773 | QUINPIROLE | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL25856 | DIHYDREXIDINE | Kd | = | 2300.0 | nM | 5.64 |
| CHEMBL1160787 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL1160787 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL59 | DOPAMINE | Kd | = | 6200.0 | nM | 5.21 |
| CHEMBL286080 | SKF-38393 | Kd | = | 46000.0 | nM | 4.34 |
| CHEMBL1160785 | — | Kd | = | 94000.0 | nM | 4.03 |