Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL670431

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(1A) dopamine receptor (CHEMBL265)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes.
Ladd DL, Weinstock J, Wise M, Gessner GW, Sawyer JL, Flaim KE.
J Med Chem (1986) 29 : 1904 -1912
PubMed 3761310 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.49 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL588 FENOLDOPAM 4.0 1 8.52
CHEMBL57672 1 7.37
CHEMBL53 APOMORPHINE 4.0 1 7.28
CHEMBL611801 1 7.24
CHEMBL59 DOPAMINE 4.0 1 6.82
CHEMBL55693 1 6.42
CHEMBL60808 1 6.16
CHEMBL299511 1 5.82
CHEMBL292611 1 5.79
CHEMBL57470 1 5.78
CHEMBL60861 1 5.76
CHEMBL54168 1 5.75
CHEMBL300995 1 5.71
CHEMBL293137 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL588 FENOLDOPAM Ki = 3.0 nM 8.52
CHEMBL57672 Ki = 43.0 nM 7.37
CHEMBL53 APOMORPHINE Ki = 53.0 nM 7.28
CHEMBL611801 Ki = 57.0 nM 7.24
CHEMBL59 DOPAMINE Ki = 150.0 nM 6.82
CHEMBL55693 Ki = 380.0 nM 6.42
CHEMBL60808 Ki = 700.0 nM 6.16
CHEMBL299511 Ki = 1500.0 nM 5.82
CHEMBL292611 Ki = 1630.0 nM 5.79
CHEMBL57470 Ki = 1650.0 nM 5.78
CHEMBL60861 Ki = 1740.0 nM 5.76
CHEMBL54168 Ki = 1790.0 nM 5.75
CHEMBL300995 Ki = 1940.0 nM 5.71
CHEMBL293137 Ki > 3000.0 nM -