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Assay Detail

CHEMBL674898

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Binding
Affinity towards Dopamine receptor D1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cercopithecidae
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(1A) dopamine receptor (CHEMBL2056)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

CoMFA-based prediction of agonist affinities at recombinant D1 vs D2 dopamine receptors.
Wilcox RE, Tseng T, Brusniak MY, Ginsburg B, Pearlman RS, Teeter M, DuRand C, Starr S, Neve KA.
J Med Chem (1998) 41 : 4385 -4399
PubMed 9784114 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.31 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL34095 1 8.52
CHEMBL317741 1 7.70
CHEMBL1160787 1 7.52
CHEMBL588 FENOLDOPAM 4.0 1 7.40
CHEMBL157138 LISURIDE 3.0 1 7.11
CHEMBL24077 (R)-SKF-38393 1 6.50
CHEMBL612083 1 5.92
CHEMBL25856 DIHYDREXIDINE 2.0 1 5.92
CHEMBL609151 1 5.87
CHEMBL225230 R-N-PROPYLNORAPOMORPHINE 1 5.82
CHEMBL531 PERGOLIDE 4.0 1 5.70
CHEMBL611801 1 5.27
CHEMBL59 DOPAMINE 4.0 1 4.74
CHEMBL145584 1 4.32
CHEMBL11608 TYRAMINE 3.0 1 -
CHEMBL240773 QUINPIROLE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL34095 Ki = 3.0 nM 8.52
CHEMBL317741 Ki = 20.0 nM 7.70
CHEMBL1160787 Ki = 30.0 nM 7.52
CHEMBL588 FENOLDOPAM Ki = 40.0 nM 7.40
CHEMBL157138 LISURIDE Ki = 77.0 nM 7.11
CHEMBL24077 (R)-SKF-38393 Ki = 320.0 nM 6.50
CHEMBL612083 Ki = 1200.0 nM 5.92
CHEMBL25856 DIHYDREXIDINE Ki = 1200.0 nM 5.92
CHEMBL609151 Ki = 1350.0 nM 5.87
CHEMBL225230 R-N-PROPYLNORAPOMORPHINE Ki = 1510.0 nM 5.82
CHEMBL531 PERGOLIDE Ki = 2020.0 nM 5.70
CHEMBL611801 Ki = 5400.0 nM 5.27
CHEMBL59 DOPAMINE Ki = 18200.0 nM 4.74
CHEMBL145584 Ki = 48000.0 nM 4.32
CHEMBL11608 TYRAMINE Ki = 390000.0 nM -
CHEMBL240773 QUINPIROLE Ki = 524810.0 nM -