Assay Detail
Binding
CHEMBL4371579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.18 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35354 | — | — | 1 | 8.70 |
| CHEMBL1196161 | — | — | 1 | 8.64 |
| CHEMBL1160787 | — | — | 1 | 7.88 |
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 7.50 |
| CHEMBL4472022 | — | — | 1 | - |
| CHEMBL574558 | — | — | 1 | - |
| CHEMBL288090 | — | — | 1 | - |
| CHEMBL1193571 | — | — | 1 | - |
| CHEMBL286080 | SKF-38393 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35354 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1196161 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1160787 | — | EC50 | = | 13.2 | nM | 7.88 |
| CHEMBL588 | FENOLDOPAM | EC50 | = | 31.7 | nM | 7.50 |
| CHEMBL4472022 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL574558 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL288090 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1193571 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL286080 | SKF-38393 | EC50 | > | 10000.0 | nM | - |