Assay Detail
Binding
CHEMBL5224065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LSD1 (unknown origin)
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Annual review of lysine-specific demethylase 1 (LSD1/KDM1A) inhibitors in 2021.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.47 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775474 | — | — | 1 | 8.54 |
| CHEMBL4749146 | — | — | 1 | 8.30 |
| CHEMBL5268105 | — | — | 1 | 7.96 |
| CHEMBL4857832 | — | — | 1 | 7.96 |
| CHEMBL4860694 | — | — | 1 | 7.77 |
| CHEMBL5276713 | — | — | 1 | 7.66 |
| CHEMBL5286191 | — | — | 1 | 7.54 |
| CHEMBL4854446 | — | — | 1 | 7.28 |
| CHEMBL5290883 | — | — | 1 | 7.21 |
| CHEMBL5182796 | — | — | 1 | 7.20 |
| CHEMBL4863608 | — | — | 1 | 7.19 |
| CHEMBL4862640 | — | — | 1 | 6.87 |
| CHEMBL5201233 | — | — | 1 | 6.85 |
| CHEMBL5204771 | — | — | 1 | 6.72 |
| CHEMBL4436792 | — | — | 1 | 6.55 |
| CHEMBL5283767 | — | — | 1 | 6.52 |
| CHEMBL5284828 | — | — | 1 | 6.40 |
| CHEMBL5282096 | — | — | 1 | 6.34 |
| CHEMBL4868123 | — | — | 1 | 6.16 |
| CHEMBL5280652 | — | — | 1 | 6.16 |
| CHEMBL5270361 | — | — | 1 | 6.09 |
| CHEMBL4864525 | — | — | 1 | 6.09 |
| CHEMBL5272643 | — | — | 1 | 6.05 |
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 6.05 |
| CHEMBL5075646 | — | — | 1 | 6.03 |
| CHEMBL5286264 | — | — | 1 | 5.99 |
| CHEMBL5274410 | — | — | 1 | 5.90 |
| CHEMBL19344 | HIGENAMINE | 1.0 | 1 | 5.83 |
| CHEMBL5093633 | — | — | 1 | 5.79 |
| CHEMBL4871961 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775474 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4749146 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4857832 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5268105 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4860694 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5276713 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5286191 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4854446 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5290883 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5182796 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4863608 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4862640 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5201233 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5204771 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4436792 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL5283767 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5284828 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5282096 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4868123 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5280652 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5270361 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4864525 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5272643 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL588 | FENOLDOPAM | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5075646 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5286264 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5274410 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL19344 | HIGENAMINE | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5093633 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4871961 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL2334501 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL5280719 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4066708 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5084881 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL5281624 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL2046709 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL3759201 | — | IC50 | = | 134000.0 | nM | - |
| CHEMBL4742730 | — | IC50 | = | 540.0 | nM | - |