Assay Detail
Binding
CHEMBL1798567
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Non-competitive inhibition of JMJD2E relative to alpha-ketoglutarate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of histone demethylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.51 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 5.72 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.45 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | Ki | = | 1920.0 | nM | 5.72 |
| CHEMBL15192 | LAPACHONE | Ki | = | 3550.0 | nM | 5.45 |
| CHEMBL8260 | BAICALEIN | Ki | = | 4330.0 | nM | 5.36 |