Assay Detail
Functional
CHEMBL4371577
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Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 9.20 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1196161 | — | — | 1 | 9.92 |
| CHEMBL574558 | — | — | 1 | 9.70 |
| CHEMBL4472022 | — | — | 1 | 9.52 |
| CHEMBL1193571 | — | — | 1 | 9.35 |
| CHEMBL35354 | — | — | 1 | 9.14 |
| CHEMBL288090 | — | — | 1 | 9.00 |
| CHEMBL286080 | SKF-38393 | — | 1 | 8.96 |
| CHEMBL1160787 | — | — | 1 | 8.70 |
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 8.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1196161 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL574558 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4472022 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1193571 | — | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL35354 | — | EC50 | = | 0.73 | nM | 9.14 |
| CHEMBL288090 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL286080 | SKF-38393 | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1160787 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL588 | FENOLDOPAM | EC50 | = | 2.8 | nM | 8.55 |