Assay Detail
Functional
CHEMBL674936
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Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzothiazol-2-one 7-ethylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.87 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 7.24 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.46 |
| CHEMBL15564 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL588 | FENOLDOPAM | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL59 | DOPAMINE | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL15564 | — | EC50 | = | 12500.0 | nM | 4.90 |