Assay Detail
Functional
CHEMBL782307
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Central dopaminergic activity was determined by testing compound for dopamine agonist activity mediated by adenylase cyclase in rat
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Separation of potent central and renal dopamine agonist activity in substituted 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.92 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353335 | — | — | 1 | 8.00 |
| CHEMBL588 | FENOLDOPAM | 4.0 | 1 | 7.75 |
| CHEMBL286080 | SKF-38393 | — | 1 | 7.10 |
| CHEMBL176938 | — | — | 1 | 6.30 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353335 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL588 | FENOLDOPAM | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL286080 | SKF-38393 | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL176938 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL59 | DOPAMINE | EC50 | = | 3500.0 | nM | 5.46 |