Dopamine receptor D2 and D3 · SELECTIVITY GROUP · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P19020. Use UniProt P19020 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P19020 as the stable identity anchor, then attach disease evidence before program review.
D(3) dopamine receptor
Review this target as Dopamine receptor D2 and D3, mapped to UniProt P19020. ChEMBL maps the protein component as D(3) dopamine receptor. Sequence length is 446 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dopamine receptor D2 and D3 as ChEMBL target CHEMBL2111342, mapped to UniProt P19020. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dopamine receptor D2 and D3 |
| Target Type | SELECTIVITY GROUP |
| Organism | Rattus norvegicus |
| UniProt | P19020 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | D(3) dopamine receptor |
| UniProt Accession | P19020 |
| Component Type | Protein |
| Sequence Length | 446 aa |
D(3) dopamine receptor
Review this target as Dopamine receptor D2 and D3, mapped to UniProt P19020. ChEMBL maps the protein component as D(3) dopamine receptor. Sequence length is 446 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL20734 | 11.0 | Kd | 0.01 | Clinical |
| CHEMBL285755 | 10.19 | EC50 | 0.064 | Preclinical |
| CHEMBL219916 | 8.99 | Ki | 1.02 | Clinical |
| CHEMBL540612 | 8.99 | IC50 | 1.02 | Preclinical |
| CHEMBL484599 | 8.82 | EC50 | 1.5 | Preclinical |
| CHEMBL301265 | 8.7 | EC50 | 1.98 | Approved |
| CHEMBL54 | 8.62 | Ki | 2.39 | Approved |
| CHEMBL589 | 8.41 | EC50 | 3.89 | Approved |
| CHEMBL531 | 8.37 | EC50 | 4.31 | Approved |
| CHEMBL715 | 8.32 | Ki | 4.8 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 9 | 6.2 |
| cell-based format | 4 | 15 | 7.8 |
| protein format | 4 | 0 | — |
| cell membrane format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 4 | 0 | — |
| cell-based format | 2 | 5 | 8.9 |