Assay Detail

CHEMBL3587607

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Binding

Binding affinity to human dopamine D4 receptor

ChEMBL ↗

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Target

D(4) dopamine receptor (CHEMBL219) ↗

Open DB target context

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D(4) dopamine receptor (CHEMBL219) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D(4) dopamine receptor

CHEMBL219

Anchored from Assay target.

Protein identity D(4) dopamine receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

D(4) dopamine receptor (CHEMBL219) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Investigation of novel ropinirole analogues: synthesis, pharmacological evaluation and computational analysis of dopamine D2 receptor functionalized congeners and homobivalent ligands

Jorg M, Kaczor AA, Mak FS, Lee KCK, Poso A, Miller ND, Scammells PJ, Capuano B
Medchemcomm (2014) 5 : 891 -898
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.11	8.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL589	ROPINIROLE	4.0	1	8.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL589	ROPINIROLE	Ki	=	7.8	nM	8.11