Assay Detail
Functional
CHEMBL3056231
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Agonist activity at Rattus norvegicus (rat) dopamine D2/D3 receptor transfected in african green monkey COS7 cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 10 min
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | COS-7 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Dopamine receptor D2 and D3 (CHEMBL2111342) ↗| Type | SELECTIVITY GROUP |
| Organism | Rattus norvegicus |
Publication
Heterodimerization of G-Protein-Coupled Receptors Reveals an Unexpected Level of Pharmacological Diversity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.90 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285755 | — | — | 1 | 10.19 |
| CHEMBL484599 | — | — | 1 | 8.82 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 8.70 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 8.41 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285755 | — | EC50 | = | 0.064 | nM | 10.19 |
| CHEMBL484599 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL301265 | PRAMIPEXOLE | EC50 | = | 1.98 | nM | 8.70 |
| CHEMBL589 | ROPINIROLE | EC50 | = | 3.89 | nM | 8.41 |
| CHEMBL531 | PERGOLIDE | EC50 | = | 4.31 | nM | 8.37 |