Assay Detail
Binding
CHEMBL981460
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone form human cloned dopamine D3 receptor expressed in CHO cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulations of the amide function of the preferential dopamine D3 agonist (R,R)-S32504: improvements of affinity and selectivity for D3 versus D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.87 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484598 | — | — | 1 | 8.38 |
| CHEMBL485128 | — | — | 1 | 8.12 |
| CHEMBL484599 | — | — | 1 | 7.83 |
| CHEMBL482556 | — | — | 1 | 7.72 |
| CHEMBL449250 | — | — | 1 | 7.71 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 7.44 |
| CHEMBL484732 | — | — | 1 | 7.42 |
| CHEMBL485352 | — | — | 1 | 7.40 |
| CHEMBL482978 | — | — | 1 | 7.02 |
| CHEMBL485325 | — | — | 1 | 6.92 |
| CHEMBL485127 | — | — | 1 | 6.05 |
| CHEMBL519201 | — | — | 1 | 5.66 |
| CHEMBL500627 | — | — | 1 | 5.61 |
| CHEMBL485018 | — | — | 1 | 5.58 |
| CHEMBL485028 | — | — | 1 | 5.56 |
| CHEMBL482977 | — | — | 1 | 5.48 |
| CHEMBL485353 | — | — | 1 | - |
| CHEMBL485017 | — | — | 1 | - |
| CHEMBL484170 | — | — | 1 | - |
| CHEMBL485029 | — | — | 1 | - |
| CHEMBL519688 | — | — | 1 | - |
| CHEMBL485027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484598 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL485128 | — | Ki | = | 7.586 | nM | 8.12 |
| CHEMBL484599 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL482556 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL449250 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL589 | ROPINIROLE | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL484732 | — | Ki | = | 38.02 | nM | 7.42 |
| CHEMBL485352 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL482978 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL485325 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL485127 | — | Ki | = | 891.25 | nM | 6.05 |
| CHEMBL519201 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL500627 | — | Ki | = | 2454.71 | nM | 5.61 |
| CHEMBL485018 | — | Ki | = | 2630.27 | nM | 5.58 |
| CHEMBL485028 | — | Ki | = | 2754.23 | nM | 5.56 |
| CHEMBL482977 | — | Ki | = | 3311.31 | nM | 5.48 |
| CHEMBL485353 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL485017 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL484170 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL485029 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL519688 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL485027 | — | Ki | > | 10000.0 | nM | - |