Assay Detail
Binding
CHEMBL1028976
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Displacement of [3H]PD128907 from dopamine D3 receptor in Sprague-Dawley rat ventral striatum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.94 | 10.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492664 | — | — | 1 | 10.37 |
| CHEMBL495327 | — | — | 1 | 9.40 |
| CHEMBL492883 | — | — | 1 | 9.39 |
| CHEMBL494511 | — | — | 1 | 9.29 |
| CHEMBL494308 | — | — | 1 | 9.13 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 9.11 |
| CHEMBL494309 | — | — | 1 | 8.66 |
| CHEMBL524005 | — | — | 1 | 8.24 |
| CHEMBL494510 | — | — | 1 | 8.12 |
| CHEMBL494509 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492664 | — | Ki | = | 0.043 | nM | 10.37 |
| CHEMBL495327 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL492883 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL494511 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL494308 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL301265 | PRAMIPEXOLE | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL494309 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL524005 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL494510 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL494509 | — | Ki | = | 23.0 | nM | 7.64 |