Assay Detail
Functional
CHEMBL5151483
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Abolishing Dopamine D<sub>2long</sub>/D<sub>3</sub> Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H<sub>2</sub> Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.64 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 9.09 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.75 |
| CHEMBL5183205 | — | — | 1 | 7.40 |
| CHEMBL5178472 | — | — | 1 | 7.17 |
| CHEMBL5176229 | — | — | 1 | 6.53 |
| CHEMBL5198795 | — | — | 1 | 6.33 |
| CHEMBL5200771 | — | — | 1 | 6.09 |
| CHEMBL5202592 | — | — | 1 | 5.98 |
| CHEMBL5208845 | — | — | 1 | 5.97 |
| CHEMBL5206565 | — | — | 1 | 5.92 |
| CHEMBL5204599 | — | — | 1 | 5.87 |
| CHEMBL5184911 | — | — | 1 | 5.72 |
| CHEMBL5207281 | — | — | 1 | 5.55 |
| CHEMBL5201074 | — | — | 1 | - |
| CHEMBL5180504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | EC50 | = | 0.8128 | nM | 9.09 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 1.778 | nM | 8.75 |
| CHEMBL5183205 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5178472 | — | EC50 | = | 67.61 | nM | 7.17 |
| CHEMBL5176229 | — | EC50 | = | 295.12 | nM | 6.53 |
| CHEMBL5198795 | — | EC50 | = | 467.74 | nM | 6.33 |
| CHEMBL5200771 | — | EC50 | = | 812.83 | nM | 6.09 |
| CHEMBL5202592 | — | EC50 | = | 1047.13 | nM | 5.98 |
| CHEMBL5208845 | — | EC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL5206565 | — | EC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL5204599 | — | EC50 | = | 1348.96 | nM | 5.87 |
| CHEMBL5184911 | — | EC50 | = | 1905.46 | nM | 5.72 |
| CHEMBL5207281 | — | EC50 | = | 2818.38 | nM | 5.55 |
| CHEMBL5201074 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5180504 | — | EC50 | > | 10000.0 | nM | - |