Assay Detail
Binding
CHEMBL2149719
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-R(+)-7-OHDPAT from dopamine D3 receptor in rat brain homogenates
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
High-affinity and selective dopamine D₃ receptor full agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 8.73 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2146499 | — | — | 1 | 9.42 |
| CHEMBL2146515 | — | — | 1 | 9.20 |
| CHEMBL2146511 | — | — | 1 | 9.17 |
| CHEMBL2146508 | — | — | 1 | 9.14 |
| CHEMBL2146503 | — | — | 1 | 9.14 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 9.11 |
| CHEMBL2146509 | — | — | 1 | 9.11 |
| CHEMBL2146506 | — | — | 1 | 9.10 |
| CHEMBL2146512 | — | — | 1 | 9.05 |
| CHEMBL2146516 | — | — | 1 | 9.03 |
| CHEMBL2146510 | — | — | 1 | 9.02 |
| CHEMBL492883 | — | — | 1 | 9.00 |
| CHEMBL2148204 | — | — | 1 | 9.00 |
| CHEMBL2148219 | — | — | 1 | 8.96 |
| CHEMBL2146481 | — | — | 1 | 8.96 |
| CHEMBL495327 | — | — | 1 | 8.96 |
| CHEMBL2148208 | — | — | 1 | 8.92 |
| CHEMBL2148209 | — | — | 1 | 8.92 |
| CHEMBL2148222 | — | — | 1 | 8.89 |
| CHEMBL2146502 | — | — | 1 | 8.82 |
| CHEMBL2146504 | — | — | 1 | 8.82 |
| CHEMBL2146505 | — | — | 1 | 8.82 |
| CHEMBL2148213 | — | — | 1 | 8.80 |
| CHEMBL2148214 | — | — | 1 | 8.80 |
| CHEMBL2148217 | — | — | 1 | 8.72 |
| CHEMBL2146500 | — | — | 1 | 8.70 |
| CHEMBL2148216 | — | — | 1 | 8.70 |
| CHEMBL2148223 | — | — | 1 | 8.68 |
| CHEMBL2148221 | — | — | 1 | 8.62 |
| CHEMBL2148207 | — | — | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2146499 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL2146515 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL2146511 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL2146508 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL2146503 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL301265 | PRAMIPEXOLE | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL2146509 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL2146506 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL2146512 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL2146516 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL2146510 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL492883 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2148204 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL495327 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2146481 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2148219 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2148208 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2148209 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2148222 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2146505 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL2146502 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL2146504 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL2148213 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2148214 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2148217 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL2146500 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2148216 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2148223 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL2148221 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL2148207 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL2148206 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL2148218 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2148220 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2146501 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL2146513 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL2146514 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2148215 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL2148210 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL2148212 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL2148211 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL2148205 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL2146507 | — | Ki | = | 41.0 | nM | 7.39 |