Assay Detail
Binding
CHEMBL4361372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D3 receptor expressed in HEK293 cell membranes measured after 90 mins by microbeta scintillation counting analysis
37
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 6.18 | 8.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 8.88 |
| CHEMBL70565 | — | — | 1 | 8.77 |
| CHEMBL4551160 | — | — | 1 | 8.73 |
| CHEMBL4471817 | — | — | 1 | 8.62 |
| CHEMBL4452064 | — | — | 1 | 8.22 |
| CHEMBL4435946 | — | — | 1 | 7.51 |
| CHEMBL4551518 | — | — | 1 | 7.39 |
| CHEMBL4443441 | — | — | 1 | 6.76 |
| CHEMBL4464060 | — | — | 1 | 6.73 |
| CHEMBL4455770 | — | — | 4 | 6.56 |
| CHEMBL4437740 | — | — | 1 | 6.55 |
| CHEMBL4525362 | — | — | 1 | 6.55 |
| CHEMBL4467736 | — | — | 2 | 6.45 |
| CHEMBL4565132 | — | — | 1 | 6.39 |
| CHEMBL4453200 | — | — | 1 | 6.37 |
| CHEMBL4519520 | — | — | 1 | 6.21 |
| CHEMBL4451708 | — | — | 1 | 6.09 |
| CHEMBL4589785 | — | — | 1 | 5.94 |
| CHEMBL4447227 | — | — | 1 | 5.92 |
| CHEMBL4460452 | — | — | 1 | 5.88 |
| CHEMBL4586223 | — | — | 1 | 5.82 |
| CHEMBL4568693 | — | — | 1 | 5.80 |
| CHEMBL4474113 | — | — | 1 | 5.67 |
| CHEMBL4465109 | — | — | 1 | 5.22 |
| CHEMBL4458742 | — | — | 1 | 5.19 |
| CHEMBL4528479 | — | — | 1 | 5.06 |
| CHEMBL4474048 | — | — | 1 | 4.95 |
| CHEMBL4562186 | — | — | 1 | 4.68 |
| CHEMBL4452139 | — | — | 1 | 4.62 |
| CHEMBL4451063 | — | — | 3 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | Ki | = | 1.32 | nM | 8.88 |
| CHEMBL70565 | — | Ki | = | 1.69 | nM | 8.77 |
| CHEMBL4551160 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL4471817 | — | Ki | = | 2.42 | nM | 8.62 |
| CHEMBL4452064 | — | Ki | = | 5.96 | nM | 8.22 |
| CHEMBL4435946 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL4551518 | — | Ki | = | 40.9 | nM | 7.39 |
| CHEMBL4443441 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL4464060 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL4455770 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL4437740 | — | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL4525362 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL4467736 | — | Ki | = | 354.0 | nM | 6.45 |
| CHEMBL4565132 | — | Ki | = | 403.0 | nM | 6.39 |
| CHEMBL4455770 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL4453200 | — | Ki | = | 424.0 | nM | 6.37 |
| CHEMBL4519520 | — | Ki | = | 613.0 | nM | 6.21 |
| CHEMBL4451708 | — | Ki | = | 806.0 | nM | 6.09 |
| CHEMBL4589785 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL4455770 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL4447227 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL4460452 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL4586223 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL4568693 | — | Ki | = | 1590.0 | nM | 5.80 |
| CHEMBL4467736 | — | Ki | = | 1770.0 | nM | 5.75 |
| CHEMBL4455770 | — | Ki | = | 2150.0 | nM | 5.67 |
| CHEMBL4474113 | — | Ki | = | 2130.0 | nM | 5.67 |
| CHEMBL4465109 | — | Ki | = | 6010.0 | nM | 5.22 |
| CHEMBL4458742 | — | Ki | = | 6470.0 | nM | 5.19 |
| CHEMBL4528479 | — | Ki | = | 8660.0 | nM | 5.06 |
| CHEMBL4474048 | — | Ki | = | 11300.0 | nM | 4.95 |
| CHEMBL4562186 | — | Ki | = | 21100.0 | nM | 4.68 |
| CHEMBL4452139 | — | Ki | = | 24200.0 | nM | 4.62 |
| CHEMBL4451063 | — | Ki | = | 26200.0 | nM | 4.58 |
| CHEMBL4451063 | — | Ki | = | 32900.0 | nM | 4.48 |
| CHEMBL4451063 | — | Ki | = | 66200.0 | nM | 4.18 |
| CHEMBL4436589 | — | Ki | = | 73000.0 | nM | 4.14 |