Compound Detail
CHEMBL1714574
TERCONAZOLE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1714574 |
| Name | TERCONAZOLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | BLSQLHNBWJLIBQ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
33
Targets
69
Activities
3
Assay Types
0
PK Parameters
20
Publications
14
Known Names
2
Indications
1
Mechanisms
Molecular Properties
532.5
MW (Da)
4.46
ALogP
8
HBA
0
HBD
64.9
PSA (Ų)
0.42
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1987 |
| Availability | Prescription |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Cytochrome P450 51 inhibitor | INHIBITOR | Lanosterol 14-alpha demethylase | ✓ | ✓ |
Indications
Candidiasis, Vulvovaginal Vaginitis
ATC Classification
G01AG02
terconazole
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
Activity Summary
IC50 36 meas. best 6.5
Ki 28 meas. best 7.21
EC50 5 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 7.21 | 7.21 | 61.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 6.71 | 5.6757 | 195.0 | 7 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 6.67 | 6.67 | 214.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.5 | 5.4543 | 317.0 | 7 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 6.43 | 6.43 | 369.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 6.4 | 6.4 | 400.0 | 1 |
| Heme oxygenase 1 CHEMBL5035 | IC50 | 6.39 | 6.39 | 410.0 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | IC50 | 6.38 | 6.38 | 418.0 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | IC50 | 6.29 | 6.29 | 508.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | IC50 | 6.01 | 6.01 | 983.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 5.9 | 5.9 | 1246.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | Ki | 5.86 | 5.86 | 1375.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 5.8 | 5.8 | 1600.0 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | Ki | 5.72 | 5.72 | 1913.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 5.63 | 5.63 | 2336.0 | 1 |
| 5-hydroxytryptamine receptor 4 CHEMBL5017 | Ki | 5.61 | 5.61 | 2463.0 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 CHEMBL4358 | IC50 | 5.61 | 5.61 | 2446.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | IC50 | 5.56 | 5.56 | 2729.0 | 1 |
| Lanosterol 14-alpha demethylase CHEMBL3849 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | Ki | 5.51 | 5.51 | 3081.0 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | Ki | 5.5 | 5.5 | 3134.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 5.44 | 5.44 | 3646.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 5.36 | 5.36 | 4347.0 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | IC50 | 5.36 | 5.36 | 4362.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | Ki | 5.34 | 5.34 | 4590.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | IC50 | 5.33 | 5.33 | 4712.0 | 1 |
| Heme oxygenase 2 CHEMBL3348 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL319 | Ki | 5.27 | 5.27 | 5374.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | IC50 | 5.26 | 5.26 | 5472.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | IC50 | 5.24 | 5.24 | 5709.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 5.22 | 5.22 | 6086.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | IC50 | 5.16 | 5.16 | 6961.0 | 1 |
| Alpha-1D adrenergic receptor CHEMBL223 | Ki | 5.15 | 5.15 | 7070.0 | 1 |
| Alpha-1B adrenergic receptor CHEMBL315 | Ki | 5.1 | 5.1 | 7915.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | IC50 | 5.09 | 5.09 | 8175.0 | 1 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL3401 | EC50 | 5.05 | 4.95 | 8900.0 | 2 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL2146315 | EC50 | 5.04 | 5.04 | 9100.0 | 1 |
| Tyrosine-protein kinase Fyn CHEMBL1841 | IC50 | 4.96 | 4.96 | 10896.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | IC50 | 4.94 | 4.94 | 11456.0 | 1 |
| SARS-CoV-2 CHEMBL4303835 | IC50 | 4.92 | 4.855 | 11920.0 | 2 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | IC50 | 4.89 | 4.89 | 12909.0 | 1 |
| D(1A) dopamine receptor CHEMBL2056 | Ki | 4.89 | 4.89 | 12740.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL319 | IC50 | 4.88 | 4.88 | 13278.0 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | IC50 | 4.86 | 4.86 | 13714.0 | 1 |
| Alpha-1B adrenergic receptor CHEMBL315 | IC50 | 4.84 | 4.84 | 14299.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | IC50 | 4.84 | 4.84 | 14537.0 | 1 |
| Alpha-1D adrenergic receptor CHEMBL223 | IC50 | 4.84 | 4.84 | 14385.0 | 1 |
| 5-hydroxytryptamine receptor 4 CHEMBL5017 | IC50 | 4.83 | 4.83 | 14780.0 | 1 |
| Acetylcholinesterase CHEMBL220 | IC50 | 4.67 | 4.67 | 21573.0 | 1 |
| ADMET CHEMBL612558 | EC50 | 4.62 | 4.62 | 24000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine