ADMET · ADMET
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Confirm a stable target identifier before relying on this context across project surfaces.
ADMET
Review this target as ADMET.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ADMET as ChEMBL target CHEMBL612558. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | ADMET |
| Target Type | ADMET |
| Organism | None |
Reviewable protein naming and mapping context for this target snapshot.
Review this target as ADMET.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL185043 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL187738 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL188103 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL1643094 | 10.92 | EC50 | 0.012 | Preclinical |
| CHEMBL43136 | 10.8 | EC50 | 0.016 | Preclinical |
| CHEMBL68131 | 10.8 | Kd | 0.01585 | Preclinical |
| CHEMBL608886 | 10.77 | IC50 | 0.017 | Preclinical |
| CHEMBL411735 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL1643090 | 10.6 | EC50 | 0.025 | Preclinical |
| CHEMBL449897 | 10.6 | IC50 | 0.0253 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 70,506 | 18 | 7.0 |
| cell-based format | 17,402 | 5,101 | 5.2 |
| assay format | 11,866 | 622 | 5.9 |
| microsome format | 11,419 | 7 | 5.4 |
| cell-free format | 6,885 | 3 | 4.8 |
| tissue-based format | 3,915 | 40 | 6.0 |
| subcellular format | 1,323 | 2 | 6.9 |
| mitochondrion format | 259 | 0 | — |
| cell membrane format | 129 | 0 | — |
| small-molecule physicochemical format | 14 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 18,862 | 3 | 5.5 |
| assay format | 3,463 | 21 | 5.2 |
| cell-based format | 2,908 | 361 | 5.1 |
| tissue-based format | 825 | 16 | 5.5 |
| subcellular format | 467 | 0 | — |
| microsome format | 29 | 0 | — |
| cell-free format | 20 | 0 | — |
| cell membrane format | 9 | 0 | — |
| mitochondrion format | 9 | 20 | 4.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 734 | 581 | 5.9 |
| cell-based format | 708 | 713 | 5.9 |
| organism-based format | 266 | 0 | — |
| cell-free format | 61 | 34 | 6.5 |
| tissue-based format | 61 | 6 | 4.3 |
| microsome format | 23 | 0 | — |
| mitochondrion format | 11 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| small-molecule physicochemical format | 248 | 0 | — |
| cell-free format | 12 | 0 | — |
| microsome format | 2 | 0 | — |
| subcellular format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 69 | 27 | 5.8 |
| cell-free format | 27 | 0 | — |
| cell-based format | 11 | 3 | 4.7 |
| organism-based format | 8 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 17 | 0 | — |
| cell-based format | 12 | 0 | — |
| organism-based format | 7 | 0 | — |