Compound Detail
CHEMBL1643
RIBAVIRIN 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1643 |
| Name | RIBAVIRIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL398463 |
74
Targets
697
Activities
4
Assay Types
7
PK Parameters
20
Publications
22
Known Names
20
Indications
3
Mechanisms
Molecular Properties
244.2
MW (Da)
-3.01
ALogP
8
HBA
4
HBD
143.7
PSA (Ų)
0.44
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1985 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Inosine-5'-monophosphate dehydrogenase 1 inhibitor | INHIBITOR | Inosine-5'-monophosphate dehydrogenase 1 | ✓ | ✓ |
| RNA-directed RNA polymerase inhibitor | INHIBITOR | RNA-directed RNA polymerase | ✓ | ✓ |
| RNA inhibitor | INHIBITOR | RNA | ✓ | ✓ |
Indications
Fibrosis Fibrosis Hepatitis C, Chronic Liver Cirrhosis Virus Diseases Depressive Disorder Hepatitis Hepatitis B, Chronic Hepatitis B, Chronic Hepatitis C HIV Infections Infections Respiratory Syncytial Virus Infections Severe Acute Respiratory Syndrome Severe Acute Respiratory Syndrome Diabetes Mellitus, Type 1 Encephalitis, Japanese Hemorrhagic Fever with Renal Syndrome Hepatitis D Influenza, Human
ATC Classification
J05AP01
ribavirin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIVIRALS FOR SYSTEMIC USE
Drug Warnings
Black Box Warning
hematological toxicity
Black Box Warning
teratogenicity
Black Box Warning
respiratory toxicity
Black Box Warning
carcinogenicity
Black Box Warning
dermatological toxicity
Activity Summary
EC50 514 meas. best 8.3
IC50 180 meas. best 8.7
Ki 2 meas. best 5.35
Kd 1 meas. best 5.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Influenza A virus CHEMBL613740 | IC50 | 8.7 | 5.026 | 2.0 | 42 |
| E6SM CHEMBL614149 | EC50 | 8.3 | 5.63 | 5.0 | 3 |
| Hepatitis C virus CHEMBL379 | IC50 | 7.4 | 4.9314 | 40.0 | 7 |
| Vesicular stomatitis virus CHEMBL613739 | IC50 | 7.34 | 7.34 | 46.0 | 1 |
| Respiratory syncytial virus CHEMBL612679 | IC50 | 7.1 | 5.1086 | 80.0 | 7 |
| Influenza B virus CHEMBL613129 | EC50 | 7.03 | 5.3 | 94.0 | 53 |
| ADMET CHEMBL612558 | EC50 | 6.17 | 5.995 | 670.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 6.0 | 5.264 | 1000.0 | 5 |
| Influenza A virus CHEMBL613740 | EC50 | 5.98 | 5.0109 | 1050.0 | 138 |
| BHK-21 CHEMBL614527 | EC50 | 5.96 | 5.96 | 1100.0 | 1 |
| dengue virus type 2 CHEMBL613966 | EC50 | 5.94 | 4.8186 | 1160.0 | 7 |
| Human orthopneumovirus CHEMBL613127 | EC50 | 5.92 | 5.36 | 1200.0 | 3 |
| Bovine viral diarrhea virus 1 CHEMBL612571 | EC50 | 5.89 | 5.2278 | 1300.0 | 9 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 5.89 | 5.0809 | 1300.0 | 11 |
| Influenza A virus H3N2 CHEMBL2366902 | EC50 | 5.85 | 5.1755 | 1400.0 | 11 |
| HeLa CHEMBL399 | EC50 | 5.82 | 5.82 | 1500.0 | 1 |
| Chikungunya virus CHEMBL4296563 | EC50 | 5.72 | 5.37 | 1890.0 | 5 |
| Respiratory syncytial virus CHEMBL612679 | EC50 | 5.7 | 4.95 | 2000.0 | 37 |
| Zika virus CHEMBL4296612 | IC50 | 5.66 | 5.224 | 2200.0 | 5 |
| Junin virus CHEMBL4523072 | EC50 | 5.6 | 4.948 | 2500.0 | 5 |
| Zika virus CHEMBL4296612 | EC50 | 5.59 | 4.741 | 2550.0 | 10 |
| Chikungunya virus CHEMBL4296563 | IC50 | 5.51 | 5.51 | 3060.0 | 1 |
| A-431 CHEMBL614069 | IC50 | 5.5 | 5.5 | 3180.0 | 1 |
| Mammarenavirus choriomeningitidis CHEMBL5291622 | EC50 | 5.46 | 5.46 | 3500.0 | 1 |
| B16-F10 CHEMBL612656 | IC50 | 5.46 | 5.46 | 3500.0 | 1 |
| MDCK CHEMBL614068 | EC50 | 5.43 | 5.43 | 3700.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.41 | 4.8669 | 3900.0 | 13 |
| dengue virus type 2 CHEMBL613966 | IC50 | 5.4 | 5.2157 | 4000.0 | 7 |
| H5N1 subtype CHEMBL613845 | EC50 | 5.37 | 4.755 | 4300.0 | 6 |
| Adenosine receptor A1 CHEMBL3688 | Ki | 5.35 | 5.35 | 4430.0 | 1 |
| Yellow fever virus CHEMBL613731 | EC50 | 5.31 | 4.93 | 4900.0 | 2 |
| MDCK CHEMBL614068 | IC50 | 5.31 | 5.05 | 4900.0 | 2 |
| Vesicular stomatitis virus CHEMBL613739 | EC50 | 5.3 | 4.7107 | 5000.0 | 15 |
| Sindbis virus CHEMBL613725 | EC50 | 5.29 | 4.795 | 5120.0 | 2 |
| Hepatitis C virus CHEMBL379 | EC50 | 5.25 | 4.4738 | 5600.0 | 24 |
| MOLT-4 CHEMBL614177 | IC50 | 5.24 | 5.24 | 5700.0 | 1 |
| H3N2 subtype CHEMBL613193 | EC50 | 5.23 | 5.11 | 5900.0 | 9 |
| dengue virus type 1 CHEMBL613360 | IC50 | 5.18 | 5.18 | 6660.0 | 1 |
| West Nile virus CHEMBL613730 | IC50 | 5.17 | 4.7433 | 6700.0 | 3 |
| SARS-CoV-2 CHEMBL4303835 | EC50 | 5.15 | 5.15 | 7100.0 | 1 |
| Adenosine receptor A1 CHEMBL226 | Ki | 5.13 | 5.13 | 7410.0 | 1 |
| Influenza B virus CHEMBL613129 | IC50 | 5.1 | 4.6971 | 8000.0 | 7 |
| Eukaryotic translation initiation factor 4E CHEMBL4848 | Kd | 5.08 | 5.08 | 8400.0 | 1 |
| Mus musculus CHEMBL375 | EC50 | 5.08 | 4.785 | 8300.0 | 2 |
| Influenza A virus (A/Puerto Rico/8/1934(H1N1)) CHEMBL612610 | EC50 | 5.06 | 4.7633 | 8700.0 | 3 |
| Human alphaherpesvirus 1 CHEMBL377 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
| Human alphaherpesvirus 1 CHEMBL377 | EC50 | 5.0 | 5.0 | 10000.0 | 1 |
| Tacaribe virus CHEMBL613131 | EC50 | 5.0 | 4.69 | 10000.0 | 3 |
| Influenza A virus H3N2 CHEMBL2366902 | IC50 | 4.97 | 4.835 | 10600.0 | 2 |
| Human respirovirus 3 CHEMBL613126 | IC50 | 4.97 | 4.97 | 10700.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 248.7 | - | Chlorocebus sabaeus |
| CL | 5.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 5.2 | mL.min-1.kg-1 | Homo sapiens |
| F | 64.0 | % | Homo sapiens |
| Fu | 1.0 | - | Homo sapiens |
| MRT | 45.0 | hr | Homo sapiens |
| T1/2 | 45.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine