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Assay Detail

CHEMBL4135029

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Human respiratory syncytial virus A2 ATCC VR 1540 infected in African green monkey Vero 76 cells assessed as protection against virus-induced cytopathic effect after 5 days by crystal violet staining-based plaque reduction assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human respiratory syncytial virus A2
Cell Type Vero 76
Confidence 1 — Organism
Curated By Intermediate

Target

Human orthopneumovirus (CHEMBL613127)
Type ORGANISM
Organism Human orthopneumovirus

Publication

Inhibitors of Yellow Fever Virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: Design, synthesis and antiviral evaluation.
Fioravanti R, Desideri N, Carta A, Atzori EM, Delogu I, Collu G, Loddo R.
Eur J Med Chem (2017) 141 : 15 -25
PubMed 29028528 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 32 5.16 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1643 RIBAVIRIN 4.0 1 5.92
CHEMBL564201 6-AZAURIDINE 1 4.40
CHEMBL1441897 1 -
CHEMBL1514645 1 -
CHEMBL1591211 1 -
CHEMBL4166223 1 -
CHEMBL4168561 1 -
CHEMBL1867917 1 -
CHEMBL1881501 1 -
CHEMBL4173042 1 -
CHEMBL4166621 1 -
CHEMBL4174536 1 -
CHEMBL4159714 1 -
CHEMBL4170341 1 -
CHEMBL4163087 1 -
CHEMBL1565276 1 -
CHEMBL4166525 1 -
CHEMBL4177143 1 -
CHEMBL4169949 1 -
CHEMBL4162022 1 -
CHEMBL4164614 1 -
CHEMBL4175245 1 -
CHEMBL4176360 1 -
CHEMBL4165746 1 -
CHEMBL4161254 1 -
CHEMBL4169180 1 -
CHEMBL4169590 1 -
CHEMBL4177444 1 -
CHEMBL4172978 1 -
CHEMBL4173795 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1643 RIBAVIRIN EC50 = 1200.0 nM 5.92
CHEMBL564201 6-AZAURIDINE EC50 = 40000.0 nM 4.40
CHEMBL4163087 EC50 > 88000.0 nM -
CHEMBL4169900 EC50 > 28000.0 nM -
CHEMBL4170341 EC50 > 29000.0 nM -
CHEMBL4159714 EC50 > 25000.0 nM -
CHEMBL4174536 EC50 > 28000.0 nM -
CHEMBL4166621 EC50 > 96000.0 nM -
CHEMBL4173042 EC50 > 35000.0 nM -
CHEMBL1881501 EC50 > 20000.0 nM -
CHEMBL1867917 EC50 > 25000.0 nM -
CHEMBL4168561 EC50 > 24000.0 nM -
CHEMBL4166223 EC50 > 21000.0 nM -
CHEMBL1591211 EC50 > 21000.0 nM -
CHEMBL1514645 EC50 > 26000.0 nM -
CHEMBL1441897 EC50 > 23000.0 nM -
CHEMBL1530025 EC50 > 24000.0 nM -
CHEMBL1565276 EC50 > 22000.0 nM -
CHEMBL4166525 EC50 > 14000.0 nM -
CHEMBL4177143 EC50 > 14000.0 nM -
CHEMBL4169949 EC50 > 20000.0 nM -
CHEMBL4162022 EC50 > 100000.0 nM -
CHEMBL4164614 EC50 > 100000.0 nM -
CHEMBL4175245 EC50 > 25000.0 nM -
CHEMBL4176360 EC50 > 90000.0 nM -
CHEMBL4165746 EC50 > 92000.0 nM -
CHEMBL4161254 EC50 > 85000.0 nM -
CHEMBL4169180 EC50 > 82000.0 nM -
CHEMBL4169590 EC50 > 100000.0 nM -
CHEMBL4177444 EC50 > 100000.0 nM -
CHEMBL4172978 EC50 > 100000.0 nM -
CHEMBL4173795 EC50 > 88000.0 nM -