Assay Detail
Functional
CHEMBL674318
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to inhibit Herpes simplex virus-1(HSV-1) / thymine kinase deficient (TK-)B2006 / VMW1837 induced cytopathicity by 50% in E6SM cell lines
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | E6SM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 8.30 |
| CHEMBL140440 | — | — | 1 | - |
| CHEMBL607985 | — | — | 1 | - |
| CHEMBL606446 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL140440 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL607985 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL606446 | — | EC50 | = | 150000.0 | nM | - |