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Target Snapshot

CHEMBL614149 Target Snapshot

E6SM · CELL-LINE · Homo sapiens

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323Compounds
333Assays
2Approved Drugs
268.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats E6SM as ChEMBL target CHEMBL614149. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
E6SM
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614149
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether E6SM still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameE6SM
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelE6SM
UniProt AccessionN/A

E6SM

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as E6SM.

Review nameE6SM
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5095.0
EC50173.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL182 8.92 EC50 1.2 Approved
CHEMBL1643 8.3 EC50 5.0 Approved
CHEMBL608312 7.1 EC50 80.0 Preclinical
CHEMBL606446 5.72 EC50 1900.0 Preclinical
CHEMBL608943 5.22 EC50 6000.0 Preclinical
CHEMBL3215377 4.35 IC50 45000.0 Preclinical
CHEMBL607985 4.31 EC50 49000.0 Preclinical
CHEMBL3217279 4.17 IC50 68000.0 Preclinical
CHEMBL608911 4.16 EC50 70000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
1
5.5
0
6.0
1
6.5
1
7.0
0
7.5
1
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

GANCICLOVIR
CHEMBL182
Approved 1989
Properties Compare Identifier
RIBAVIRIN
CHEMBL1643
Approved 1985
Properties Compare Identifier
Assay Landscape

Assay Landscape

333
Total Assays
9
Tested Compounds
2
Assay Types
Functional — 324 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 324 9 5.8
ADME — 9 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine