Assay Detail
Functional
CHEMBL2421565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against influenza A virus H3N3 subtype infected in dog MDCK cells assessed as reduction of virus-induced cytopathogenicity by MTS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.05 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 8.00 |
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 7.70 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 6.52 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.96 |
| CHEMBL2418404 | — | — | 1 | - |
| CHEMBL2418403 | — | — | 1 | - |
| CHEMBL2418402 | — | — | 1 | - |
| CHEMBL2418401 | — | — | 1 | - |
| CHEMBL2418400 | — | — | 1 | - |
| CHEMBL2418399 | — | — | 1 | - |
| CHEMBL2418398 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1229 | OSELTAMIVIR | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL660 | AMANTADINE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2418404 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2418403 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2418402 | — | EC50 | > | 800.0 | nM | - |
| CHEMBL2418401 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2418400 | — | EC50 | > | 160.0 | nM | - |
| CHEMBL2418399 | — | EC50 | > | 160.0 | nM | - |
| CHEMBL2418398 | — | EC50 | > | 160.0 | nM | - |