Assay Detail
Functional
CHEMBL5587035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Vesicular stomatitis virus infected in African green monkey Vero cells assessed as inhibition of cytopathic effect pre-infected with cells for 12 hrs followed by viral infection and measured after 24 hrs by fluorescence based CPE reduction method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vesicular stomatitis virus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Vesicular stomatitis virus (CHEMBL613739) ↗| Type | ORGANISM |
| Organism | Vesicular stomatitis virus |
Publication
Antiviral Chlorinated Drimane Meroterpenoids from the Fungus <i>Talaromyces pinophilus</i> LD-7 and Their Biosynthetic Pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.80 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598200 | — | — | 1 | 7.82 |
| CHEMBL5598314 | — | — | 1 | 7.75 |
| CHEMBL5597201 | — | — | 1 | 7.64 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 7.34 |
| CHEMBL5597620 | — | — | 1 | 7.09 |
| CHEMBL5598312 | — | — | 1 | 7.08 |
| CHEMBL5597725 | — | — | 1 | 6.89 |
| CHEMBL5596765 | — | — | 1 | 6.75 |
| CHEMBL5597107 | — | — | 1 | 6.72 |
| CHEMBL5598491 | — | — | 1 | 6.58 |
| CHEMBL5597448 | — | — | 1 | 6.55 |
| CHEMBL5597067 | — | — | 1 | 6.50 |
| CHEMBL5596445 | — | — | 1 | 6.37 |
| CHEMBL5596902 | — | — | 1 | 6.31 |
| CHEMBL5598478 | — | — | 1 | 6.24 |
| CHEMBL5597183 | — | — | 1 | 6.04 |
| CHEMBL5589841 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598200 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5598314 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5597201 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1643 | RIBAVIRIN | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5597620 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5598312 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5597725 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5596765 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5597107 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5598491 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5597448 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5597067 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5596445 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5596902 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5598478 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5597183 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5589841 | — | IC50 | = | 970.0 | nM | 6.01 |