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Target Snapshot

CHEMBL375 Target Snapshot

Mus musculus · ORGANISM · Mus musculus

72,342Compounds
109,118Assays
58Approved Drugs
3,763.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mus musculus as ChEMBL target CHEMBL375. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mus musculus
ORGANISM · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL375
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mus musculus still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMus musculus
UniProt AccessionN/A

Mus musculus

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mus musculus.

Review nameMus musculus
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

58
Approved
8
Phase III
30
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC502,727.0
KI164.0
EC50780.0
KD92.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL423102 11.0 IC50 0.01 Preclinical
CHEMBL1720855 10.85 IC50 0.014 Preclinical
CHEMBL108730 10.7 EC50 0.02 Preclinical
CHEMBL3265375 10.44 EC50 0.036 Preclinical
CHEMBL433978 10.42 IC50 0.038 Preclinical
CHEMBL3265378 10.41 EC50 0.039 Preclinical
CHEMBL3265379 10.41 EC50 0.039 Preclinical
CHEMBL3265377 10.32 EC50 0.048 Preclinical
CHEMBL3265381 10.32 EC50 0.048 Preclinical
CHEMBL3265380 10.29 EC50 0.051 Preclinical
Distribution

pChEMBL Value Distribution

315
5.0
229
5.5
225
6.0
209
6.5
230
7.0
206
7.5
183
8.0
136
8.5
104
9.0
37
9.5
pChEMBL
Approved Drugs

Approved Drugs

ETRASIMOD
CHEMBL3358920
Approved 2023
FINGOLIMOD
CHEMBL314854
Approved 2010
FINGOLIMOD HYDROCHLORIDE
CHEMBL544665
Approved 2010
RIMONABANT
CHEMBL111
Approved 2006
ZOLEDRONIC ACID
CHEMBL4303669
Approved 2001
ALITRETINOIN
CHEMBL705
Approved 1999
SIROLIMUS
CHEMBL413
Approved 1999
RISEDRONIC ACID
CHEMBL923
Approved 1998
OLANZAPINE
CHEMBL715
Approved 1996
ALENDRONIC ACID
CHEMBL870
Approved 1995
TACROLIMUS ANHYDROUS
CHEMBL269732
Approved 1994
TACRINE
CHEMBL95
Approved 1993
PAMIDRONIC ACID
CHEMBL834
Approved 1991
ZIDOVUDINE
CHEMBL129
Approved 1987
DRONABINOL
CHEMBL465
Approved 1985
MORPHINE
CHEMBL70
Approved 1984
PENTAMIDINE
CHEMBL55
Approved 1984
NICOTINE
CHEMBL3
Approved 1984
CYCLOSPORINE
CHEMBL160
Approved 1983
BUPRENORPHINE
CHEMBL511142
Approved 1981
PENTAGASTRIN
CHEMBL1328
Approved 1974
DOXORUBICIN
CHEMBL53463
Approved 1974
NALOXONE
CHEMBL80
Approved 1971
TRETINOIN
CHEMBL38
Approved 1971
FENTANYL
CHEMBL596
Approved 1968
INDOMETHACIN
CHEMBL6
Approved 1965
DESIPRAMINE
CHEMBL72
Approved 1964
NORTRIPTYLINE
CHEMBL445
Approved 1964
OXYMORPHONE
CHEMBL963
Approved 1959
IMIPRAMINE
CHEMBL11
Approved 1959
DEXAMETHASONE
CHEMBL384467
Approved 1958
PREDNISOLONE
CHEMBL131
Approved 1955
METHOTREXATE
CHEMBL34259
Approved 1953
HYDROCORTISONE
CHEMBL389621
Approved 1952
Source · ChEMBL 36 via Core Engine