Review anchor
Mus musculus
ORGANISM · Mus musculus
As of 2026-09-13
Evidence Snapshot
Mus musculus
CHEMBL375
ORGANISM
Mus musculus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mus musculus as ChEMBL target CHEMBL375. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL375
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Mus musculus matters
Mus musculus is reviewed as Mus musculus; the current evidence base includes 58 approved drugs, 72342 compounds, and 109118 assays, with lead potency reaching pChEMBL 11.0.
Protein context
Mus musculus
Mus musculus
Review this target as Mus musculus.
Protein source · UniProt accession via ChEMBL component mappingDisease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 58 approved drugs, 72342 compounds, and 109118 assays for this target. The dominant activity type is IC50. CHEMBL423102 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL423102 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
58 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Mus musculus matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
72342
Total Compounds
109118
Total Assays
58
Approved Drugs
IC50: 2727.0, KI: 164.0, EC50: 780.0, KD: 92.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL423102
|
11.0 | IC50 | — |
|
|
No preferred name
CHEMBL1720855
|
10.8 | IC50 | — |
|
|
No preferred name
CHEMBL108730
|
10.7 | EC50 | — |
|
|
No preferred name
CHEMBL3265375
|
10.4 | EC50 | — |
|
|
No preferred name
CHEMBL433978
|
10.4 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
ETRASIMOD
CHEMBL3358920
|
2023 |
|
|
FINGOLIMOD
CHEMBL314854
|
2010 |
|
|
FINGOLIMOD HYDROCHLORIDE
CHEMBL544665
|
2010 |
|
|
RIMONABANT
CHEMBL111
|
2006 |
|
|
ZOLEDRONIC ACID
CHEMBL4303669
|
2001 |
|
|
ALITRETINOIN
CHEMBL705
|
1999 |
|
|
SIROLIMUS
CHEMBL413
|
1999 |
|
|
RISEDRONIC ACID
CHEMBL923
|
1998 |
|
|
OLANZAPINE
CHEMBL715
|
1996 |
|
|
ALENDRONIC ACID
CHEMBL870
|
1995 |
|
|
TACROLIMUS ANHYDROUS
CHEMBL269732
|
1994 |
|
|
TACRINE
CHEMBL95
|
1993 |
|
|
PAMIDRONIC ACID
CHEMBL834
|
1991 |
|
|
ZIDOVUDINE
CHEMBL129
|
1987 |
|
|
DRONABINOL
CHEMBL465
|
1985 |
|
|
MORPHINE
CHEMBL70
|
1984 |
|
|
PENTAMIDINE
CHEMBL55
|
1984 |
|
|
NICOTINE
CHEMBL3
|
1984 |
|
|
CYCLOSPORINE
CHEMBL160
|
1983 |
|
|
BUPRENORPHINE
CHEMBL511142
|
1981 |
|
|
PENTAGASTRIN
CHEMBL1328
|
1974 |
|
|
DOXORUBICIN
CHEMBL53463
|
1974 |
|
|
NALOXONE
CHEMBL80
|
1971 |
|
|
TRETINOIN
CHEMBL38
|
1971 |
|
|
FENTANYL
CHEMBL596
|
1968 |
|
|
INDOMETHACIN
CHEMBL6
|
1965 |
|
|
DESIPRAMINE
CHEMBL72
|
1964 |
|
|
NORTRIPTYLINE
CHEMBL445
|
1964 |
|
|
OXYMORPHONE
CHEMBL963
|
1959 |
|
|
IMIPRAMINE
CHEMBL11
|
1959 |
|
|
DEXAMETHASONE
CHEMBL384467
|
1958 |
|
|
PREDNISOLONE
CHEMBL131
|
1955 |
|
|
METHOTREXATE
CHEMBL34259
|
1953 |
|
|
HYDROCORTISONE
CHEMBL389621
|
1952 |
Source Header