Compound Detail
CHEMBL80
NALOXONE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL80 |
| Name | NALOXONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | UZHSEJADLWPNLE-GRGSLBFTSA-N |
| Therapeutic | ✓ Yes |
21
Targets
199
Activities
4
Assay Types
30
PK Parameters
20
Publications
4
Known Names
20
Indications
Molecular Properties
327.4
MW (Da)
1.30
ALogP
5
HBA
2
HBD
70.0
PSA (Ų)
0.80
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1971 |
| Availability | OTC |
| Chirality | Single Enantiomer |
Indications
Constipation Chronic Pain Epilepsy Heroin Dependence Low Back Pain Morphine Dependence Mycosis Fungoides Opioid-Related Disorders Opioid-Related Disorders Osteoarthritis Pain Parkinson Disease Restless Legs Syndrome Sezary Syndrome Substance Withdrawal Syndrome Substance-Related Disorders Diabetes Mellitus, Type 1 Diabetic Neuropathies Feeding and Eating Disorders Hypogonadism
ATC Classification
A06AH04
naloxone
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS FOR CONSTIPATION
V03AB15
naloxone
Level 1: VARIOUS
Level 2: ALL OTHER THERAPEUTIC PRODUCTS
Activity Summary
Ki 113 meas. best 9.64
IC50 59 meas. best 8.85
Kd 21 meas. best 9.66
EC50 6 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL233 | Kd | 9.66 | 9.66 | 0.2 | 2 |
| Mu-type opioid receptor CHEMBL233 | Ki | 9.64 | 8.4631 | 0.2 | 26 |
| Kappa-type opioid receptor CHEMBL237 | Ki | 9.6 | 8.1756 | 0.2 | 16 |
| Mu-type opioid receptor CHEMBL270 | Kd | 9.4 | 8.74 | 0.4 | 3 |
| Mu-type opioid receptor CHEMBL4354 | Ki | 9.17 | 8.8067 | 0.7 | 9 |
| Opioid receptor CHEMBL2094129 | Kd | 9.0 | 7.905 | 1.0 | 2 |
| Kappa-type opioid receptor CHEMBL3614 | Kd | 9.0 | 8.675 | 1.0 | 2 |
| Mu-type opioid receptor CHEMBL270 | Ki | 8.97 | 8.5967 | 1.1 | 6 |
| Unchecked CHEMBL612545 | Ki | 8.96 | 7.9743 | 1.1 | 7 |
| Opioid receptor CHEMBL2094129 | IC50 | 8.85 | 8.0583 | 1.4 | 6 |
| Opioid receptor CHEMBL2094129 | EC50 | 8.82 | 8.82 | 1.5 | 1 |
| Kappa-type opioid receptor CHEMBL237 | IC50 | 8.82 | 7.318 | 1.5 | 5 |
| Opioid receptors; mu/kappa/delta CHEMBL2095181 | IC50 | 8.8 | 7.95 | 1.6 | 4 |
| Mu-type opioid receptor CHEMBL4354 | Kd | 8.73 | 8.615 | 1.9 | 2 |
| Mu-type opioid receptor CHEMBL233 | IC50 | 8.73 | 7.618 | 1.9 | 15 |
| Delta-type opioid receptor CHEMBL269 | Ki | 8.62 | 7.8867 | 2.4 | 6 |
| Mus musculus CHEMBL375 | Kd | 8.53 | 8.53 | 3.0 | 1 |
| Kappa-type opioid receptor CHEMBL3952 | Ki | 8.51 | 8.0144 | 3.1 | 18 |
| Mu-type opioid receptor CHEMBL3041 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 8.2 | 8.12 | 6.3 | 2 |
| Rattus norvegicus CHEMBL376 | IC50 | 8.19 | 7.6367 | 6.4 | 3 |
| Kappa-type opioid receptor CHEMBL237 | EC50 | 8.18 | 8.09 | 6.6 | 2 |
| Mu-type opioid receptor CHEMBL233 | EC50 | 8.06 | 8.06 | 8.6 | 1 |
| Opioid receptors; mu & kappa CHEMBL2095156 | IC50 | 8.05 | 7.475 | 9.0 | 2 |
| Mu-type opioid receptor CHEMBL4354 | IC50 | 8.05 | 8.05 | 8.9 | 2 |
| Rattus norvegicus CHEMBL376 | Kd | 8.0 | 8.0 | 10.0 | 1 |
| Mu-type opioid receptor CHEMBL2858 | Kd | 7.99 | 7.99 | 10.2 | 1 |
| C-C chemokine receptor type 5 CHEMBL3676 | Kd | 7.98 | 7.83 | 10.5 | 2 |
| Mu-type opioid receptor CHEMBL2858 | IC50 | 7.81 | 7.81 | 15.4 | 1 |
| Delta-type opioid receptor CHEMBL236 | Ki | 7.8 | 7.2126 | 15.8 | 23 |
| Delta-type opioid receptor CHEMBL269 | Kd | 7.75 | 7.75 | 18.0 | 1 |
| Kappa-type opioid receptor CHEMBL3952 | Kd | 7.7 | 7.7 | 19.9 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.64 | 7.64 | 23.0 | 1 |
| Delta-type opioid receptor CHEMBL3222 | Kd | 7.35 | 7.325 | 44.7 | 2 |
| Kappa-type opioid receptor CHEMBL3952 | IC50 | 7.3 | 7.3 | 50.0 | 2 |
| Delta-type opioid receptor CHEMBL236 | IC50 | 7.21 | 6.8436 | 62.0 | 11 |
| Kappa-type opioid receptor CHEMBL4329 | Kd | 6.9 | 6.9 | 125.9 | 1 |
| Cytochrome b-245 heavy chain CHEMBL1287627 | IC50 | 5.71 | 5.71 | 1960.0 | 1 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 117.0 | ng.hr.mL-1 | Canis lupus familiaris |
| AUC | 122.0 | ng.hr.mL-1 | Canis lupus familiaris |
| CL | 48.8 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 42.5 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 25.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 19.5 | mL.min-1.kg-1 | Homo sapiens |
| CL | 23.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 23.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 19.3 | mL.min-1.kg-1 | Homo sapiens |
| CL | 14.1 | mL.min-1.kg-1 | Homo sapiens |
| CL | - | mL.min-1.kg-1 | Homo sapiens |
| CL | 21.7 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.292 | mL.min-1.g-1 | Homo sapiens |
| CL | 0.675 | mL.min-1.g-1 | Homo sapiens |
| CL | 2.22 | mL.min-1.g-1 | Homo sapiens |
| CL | 0.01 | mL.min-1.g-1 | Homo sapiens |
| CL | 0.14 | mL.min-1.g-1 | Homo sapiens |
| CL | 0.402 | mL.min-1.g-1 | Homo sapiens |
| CL | 14.2 | mL.min-1.g-1 | Homo sapiens |
| CL | 0.502 | mL.min-1.g-1 | Homo sapiens |
| CL | 52.7 | mL.min-1.g-1 | Homo sapiens |
| CL | 10.9 | mL.min-1.g-1 | Homo sapiens |
| CL | 55.6 | mL.min-1.g-1 | Homo sapiens |
| CL | 10.0 | mL.min-1.g-1 | Homo sapiens |
| Cmax | 131.35 | nM | Canis lupus familiaris |
| Cmax | 598.69 | nM | Canis lupus familiaris |
| F | 20.0 | % | Homo sapiens |
| F | 2.0 | % | Homo sapiens |
| F | 9.6 | % | Canis lupus familiaris |
| Fu | 0.54 | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine