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Assay Detail

CHEMBL893119

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Brain
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Expert

Target

Mu-type opioid receptor (CHEMBL4354)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Synthesis of bridged piperazines with sigma receptor affinity.
Weigl M, Wünsch B.
Eur J Med Chem (2007) 42 : 1247 -1262
PubMed 17420073 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 6.34 9.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL80 NALOXONE 4.0 1 9.17
CHEMBL429103 1 5.48
CHEMBL242077 1 5.39
CHEMBL395304 1 5.30
CHEMBL396978 1 -
CHEMBL244450 1 -
CHEMBL244449 1 -
CHEMBL394352 1 -
CHEMBL244652 1 -
CHEMBL244650 1 -
CHEMBL242297 1 -
CHEMBL395069 1 -
CHEMBL390022 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL80 NALOXONE Ki = 0.68 nM 9.17
CHEMBL429103 Ki = 3320.0 nM 5.48
CHEMBL242077 Ki = 4050.0 nM 5.39
CHEMBL395304 Ki = 4960.0 nM 5.30
CHEMBL396978 Ki - -
CHEMBL244450 Ki - -
CHEMBL244449 Ki - -
CHEMBL394352 Ki - -
CHEMBL244652 Ki - -
CHEMBL244650 Ki - -
CHEMBL242297 Ki - -
CHEMBL395069 Ki - -
CHEMBL390022 Ki - -