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Target Snapshot

CHEMBL2094129 Target Snapshot

Opioid receptor · PROTEIN FAMILY · Rattus norvegicus

531Compounds
146Assays
29Approved Drugs
711.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P33533. Use UniProt P33533 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P33533 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Opioid receptor as ChEMBL target CHEMBL2094129, mapped to UniProt P33533. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Opioid receptor
PROTEIN FAMILY · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL2094129
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P33533
Delta-type opioid receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Opioid receptor is the right protein anchor across sources, using UniProt P33533 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDelta-type opioid receptor
UniProt AccessionP33533
Component TypeProtein
Sequence Length372 aa

Delta-type opioid receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Opioid receptor, mapped to UniProt P33533. ChEMBL maps the protein component as Delta-type opioid receptor. Sequence length is 372 aa.

Mapped IDP33533
Review nameOpioid receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

29
Approved
2
Phase III
11
Phase II
Assay Mix

Activity Type Distribution

IC50505.0
KI116.0
EC5076.0
KD14.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL963 10.89 IC50 0.013 Approved
CHEMBL293967 10.82 IC50 0.015 Preclinical
CHEMBL606711 10.7 IC50 0.02 Preclinical
CHEMBL658 10.7 Ki 0.02 Approved
CHEMBL556578 10.3 IC50 0.05 Clinical
CHEMBL540269 10.1 IC50 0.08 Preclinical
CHEMBL606767 10.07 IC50 0.085 Preclinical
CHEMBL101535 10.0 Ki 0.1 Preclinical
CHEMBL171763 10.0 IC50 0.1 Preclinical
CHEMBL606643 9.7 IC50 0.2 Preclinical
Distribution

pChEMBL Value Distribution

36
5.0
32
5.5
46
6.0
51
6.5
67
7.0
65
7.5
74
8.0
49
8.5
40
9.0
10
9.5
pChEMBL
Approved Drugs

Approved Drugs

APOMORPHINE
CHEMBL53
Approved 2001
ALFENTANIL
CHEMBL634
Approved 1986
SUFENTANIL
CHEMBL658
Approved 1984
NALTREXONE
CHEMBL19019
Approved 1984
HYDROMORPHONE HYDROCHLORIDE
CHEMBL1237055
Approved 1984
MORPHINE
CHEMBL70
Approved 1984
MORPHINE SULFATE
CHEMBL2103744
Approved 1984
LEVALLORPHAN
CHEMBL1254682
Approved 1982
BUPRENORPHINE
CHEMBL511142
Approved 1981
NALOXONE
CHEMBL80
Approved 1971
FENTANYL
CHEMBL596
Approved 1968
OXYMORPHONE
CHEMBL963
Approved 1959
OXYMORPHONE HYDROCHLORIDE
CHEMBL1200794
Approved 1959
CODEINE PHOSPHATE
CHEMBL6067642
Approved 1952
METHADONE HYDROCHLORIDE
CHEMBL1200825
Approved 1947
MEPERIDINE
CHEMBL607
Approved 1942
Assay Landscape

Assay Landscape

146
Total Assays
362
Tested Compounds
2
Assay Types
Binding — 142 assays, 362 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 42 103 7.2
cell membrane format 35 81 7.6
protein format 34 68 7.0
assay format 30 108 7.6
organism-based format 1 2 8.1
Functional — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 4 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine