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Compound Detail

CHEMBL2103744

MORPHINE SULFATE
💊 Approved Drug
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💊 Approved Drug
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.O.O.O.O.O.O=S(=O)(O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2103744
Name MORPHINE SULFATE
Phase Approved
Structure Type MOL
InChI Key GRVOTVYEFDAHCL-RTSZDRIGSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL70
Active Moiety CHEMBL70

Known Names

Arymo Arymo er Astramorph Astramorph pf Avinza Depodur Dolcontin Duramorph Duramorph pf Duromorph Filnarine sr Infumorph +18 more
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
30
Known Names
20
Indications
1
Mechanisms

Molecular Properties

285.3
MW (Da)
1.20
ALogP
4
HBA
2
HBD
52.9
PSA (Ų)
0.70
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1984
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral Parenteral

Flags

Black Box Warning

Extended Properties

Molecular Formula C34H50N2O15S
MW 758.84
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness 2.59

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Mu opioid receptor agonist AGONIST Mu-type opioid receptor ✓ ✓

Indications

Acute Pain Chronic Pain Drug Overdose Neoplasms Pain Pain, Postoperative Substance-Related Disorders Cancer Pain Idiopathic Pulmonary Fibrosis Opioid-Related Disorders Opioid-Related Disorders Pruritus Sleep Apnea, Obstructive Anemia, Sickle Cell Hallux Valgus Hypertension, Pulmonary Myocardial Infarction Neonatal Abstinence Syndrome Osteoarthritis, Knee Low Back Pain

Drug Warnings

Black Box Warning
respiratory toxicity
Country: United States
Black Box Warning
misuse
Country: United States

Activity Summary

IC50 2 meas. best 7.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Opioid receptor
CHEMBL2094129
 IC50 7.66 7.66 22.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Opioid receptor IC50 = 22.0 nM 7.66 Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor ... 209186

Literature References

PubMed DOI Target Context # Activities
32530286 10.1021/acs.jmedchem.0c00503 ADMET 8
32530286 10.1021/acs.jmedchem.0c00503 Mus musculus 4
209186 10.1021/jm00205a003 Opioid receptor 2
209186 10.1021/jm00205a003 Mus musculus 2

Data from ChEMBL 36 via Core Engine