Assay Detail
Binding
CHEMBL3257740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation counting
19
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebellum |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.57 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3249801 | — | — | 2 | 8.35 |
| CHEMBL3249802 | — | — | 2 | 7.72 |
| CHEMBL2103744 | MORPHINE SULFATE | 4.0 | 2 | 7.66 |
| CHEMBL1200825 | METHADONE HYDROCHLORIDE | 4.0 | 2 | 7.29 |
| CHEMBL13786 | — | — | 1 | 7.05 |
| CHEMBL3249804 | — | — | 1 | 6.50 |
| CHEMBL3249418 | — | — | 4 | 6.22 |
| CHEMBL3249805 | — | — | 1 | 6.00 |
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | 4.0 | 2 | 5.00 |
| CHEMBL3249803 | — | — | 2 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3249801 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3249802 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2103744 | MORPHINE SULFATE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1200825 | METHADONE HYDROCHLORIDE | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL13786 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3249804 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3249418 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3249805 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3249418 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3249803 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3249801 | — | IC50 | = | 4466835.92 | nM | - |
| CHEMBL2103744 | MORPHINE SULFATE | IC50 | = | 21877616.24 | nM | - |
| CHEMBL1200825 | METHADONE HYDROCHLORIDE | IC50 | = | 51286138.4 | nM | - |
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | IC50 | = | 100000000.0 | nM | - |
| CHEMBL3249802 | — | IC50 | = | 19054607.18 | nM | - |
| CHEMBL3249803 | — | IC50 | = | 100000000.0 | nM | - |
| CHEMBL3249418 | — | IC50 | = | 602559586.07 | nM | - |
| CHEMBL3249418 | — | IC50 | = | 331131121.48 | nM | - |