Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1200825

METHADONE HYDROCHLORIDE
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1.Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1200825
Name METHADONE HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key FJQXCDYVZAHXNS-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL651
Active Moiety CHEMBL651

Known Names

Adanon hydrochloride AN-148 Butalgin Dolofin hydrochloride Dolophine Dolophine hydrochloride Eptadone Fenadone Heptadon Ketalgin hydrochloride Martindale Mecodin +13 more
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
25
Known Names
6
Indications
1
Mechanisms

Molecular Properties

309.4
MW (Da)
4.29
ALogP
2
HBA
0
HBD
20.3
PSA (Ų)
0.76
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1947
Availability Prescription
Chirality Racemic

Routes of Administration

Oral Parenteral

Flags

Black Box Warning

Extended Properties

Molecular Formula C21H28ClNO
MW 345.91
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.20

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Mu opioid receptor agonist AGONIST Mu-type opioid receptor ✓ ✓

Indications

Acute Pain Opioid-Related Disorders Pain Substance-Related Disorders HIV Infections Intervertebral Disc Degeneration

Drug Warnings

Black Box Warning
misuse
Country: United States
Black Box Warning
respiratory toxicity
Country: United States
Black Box Warning
cardiotoxicity
Country: United States

Activity Summary

IC50 2 meas. best 7.29

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Opioid receptor
CHEMBL2094129
 IC50 7.29 7.29 51.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Opioid receptor IC50 = 51.0 nM 7.29 Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor ... 209186

Literature References

PubMed DOI Target Context # Activities
209186 10.1021/jm00205a003 Opioid receptor 2
209186 10.1021/jm00205a003 Mus musculus 2

Data from ChEMBL 36 via Core Engine