Mu-type opioid receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Mu-type opioid receptor shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block. 21 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P35372. Start with pain, then reuse UniProt P35372 as the stable protein anchor across project notes and exports.
Start with pain, then reuse UniProt P35372 as the stable protein anchor across project notes and exports.
Mu-type opioid receptor shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block. 21 linked drugs remain visible in the same block.
Start review with pain because it currently carries approved-linked support. Linked drugs include AXOMADOL, BUPRENORPHINE, DEZOCINE, DIHYDROCODEINE BITARTRATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMu-type opioid receptor
Review this target as Mu-type opioid receptor, mapped to UniProt P35372. Sequence length is 400 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mu-type opioid receptor as ChEMBL target CHEMBL233, mapped to UniProt P35372. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Mu-type opioid receptor is the right protein anchor across sources, using UniProt P35372 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why pain is currently framed as approved-linked support. It currently carries 21 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Mu-type opioid receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35372 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mu-type opioid receptor |
| UniProt Accession | P35372 |
| Component Type | Protein |
| Sequence Length | 400 aa |
Mu-type opioid receptor
Review this target as Mu-type opioid receptor, mapped to UniProt P35372. Sequence length is 400 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Mu-type opioid receptor shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block.
Start review with pain because it currently carries approved-linked support. Linked drugs include AXOMADOL, BUPRENORPHINE, DEZOCINE, DIHYDROCODEINE BITARTRATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL199832 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL326684 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL58362 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL5175179 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL4550234 | 10.96 | Ki | 0.0109 | Preclinical |
| CHEMBL4450250 | 10.96 | Ki | 0.0109 | Preclinical |
| CHEMBL4521879 | 10.96 | Ki | 0.0109 | Preclinical |
| CHEMBL4439415 | 10.96 | Ki | 0.0109 | Preclinical |
| CHEMBL443311 | 10.9 | IC50 | 0.0125 | Preclinical |
| CHEMBL331883 | 10.89 | Ki | 0.013 | Preclinical |