Skip to main content
Evidence Snapshot

Mu-type opioid receptor

CHEMBL233 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T14:18:33Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL233
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mu-type opioid receptor as ChEMBL target CHEMBL233, mapped to UniProt P35372. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mu-type opioid receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL233
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P35372
Mu-type opioid receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Mu-type opioid receptor matters

As of 2026-09-13

Mu-type opioid receptor is reviewed as Mu-type opioid receptor (UniProt P35372); Mu-type opioid receptor shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block.; 21 linked drugs keep this evidence frame grounded.; the current evidence base includes 130 approved drugs, 13324 compounds, and 2047 assays, with lead potency reaching pChEMBL 11.0.

Disease context
pain

Mu-type opioid receptor shows approved-linked disease relevance led by pain. 5 more disease programs remain visible in the same review block. 21 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include AXOMADOL, BUPRENORPHINE, DEZOCINE.

Start review with pain because it currently carries approved-linked support. Linked drugs include AXOMADOL, BUPRENORPHINE, DEZOCINE, DIHYDROCODEINE BITARTRATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Approved-linked 21 linked drugs
Activity base
Portfolio and assay base

ChEMBL currently tracks 130 approved drugs, 13324 compounds, and 2047 assays for this target. The dominant activity type is KI. CHEMBL199832 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL199832 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
130 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Mu-type opioid receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P35372, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why pain is currently treated as approved-linked support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

13324
Total Compounds
2047
Total Assays
130
Approved Drugs
IC50: 3534.0, KI: 8725.0, EC50: 3725.0, KD: 42.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL199832
 11.0 Ki —
No preferred name
CHEMBL326684
 11.0 Ki —
No preferred name
CHEMBL58362
 11.0 Ki —
No preferred name
CHEMBL5175179
 11.0 Ki —
No preferred name
CHEMBL4550234
 11.0 Ki —

Approved Drugs

Structure Compound First Approval
SAMIDORPHAN
CHEMBL426084
 2021
OLICERIDINE
CHEMBL2443262
 2020
CANNABIDIOL
CHEMBL190461
 2018
NALDEMEDINE
CHEMBL2105755
 2017
ELUXADOLINE
CHEMBL2159122
 2015
VILAZODONE HYDROCHLORIDE
CHEMBL1615374
 2011
NALFURAFINE HYDROCHLORIDE
CHEMBL490665
 2009
TOLVAPTAN
CHEMBL344159
 2009
NALFURAFINE
CHEMBL267495
 2009
ALVIMOPAN
CHEMBL270190
 2008
TAPENTADOL
CHEMBL1201776
 2008
METHYLNALTREXONE BROMIDE
CHEMBL1201770
 2008
METHYLNALTREXONE
CHEMBL1186579
 2008
FROVATRIPTAN SUCCINATE
CHEMBL2138684
 2001
MIFEPRISTONE
CHEMBL1276308
 2000
RALOXIFENE
CHEMBL81
 1997
NALMEFENE
CHEMBL982
 1995
LEVORPHANOL
CHEMBL592
 1991
DEZOCINE
CHEMBL1685
 1989
ASTEMIZOLE
CHEMBL296419
 1988
ALFENTANIL HYDROCHLORIDE
CHEMBL1200531
 1986
PIMOZIDE
CHEMBL1423
 1984
MORPHINE
CHEMBL70
 1984
HYDROMORPHONE
CHEMBL398707
 1984
SUFENTANIL
CHEMBL658
 1984
NALTREXONE
CHEMBL19019
 1984
LEVALLORPHAN
CHEMBL1254682
 1982
GENTIAN VIOLET
CHEMBL64894
 1982
BUPRENORPHINE HYDROCHLORIDE
CHEMBL2368861
 1981
BUPRENORPHINE
CHEMBL511142
 1981
NALBUPHINE
CHEMBL895
 1979
BUTORPHANOL
CHEMBL33986
 1978
LOPERAMIDE
CHEMBL841
 1976
LOPERAMIDE HYDROCHLORIDE
CHEMBL1707
 1976
CLOTRIMAZOLE
CHEMBL104
 1975
NALOXONE
CHEMBL80
 1971
FENTANYL
CHEMBL596
 1968
HALOPERIDOL
CHEMBL54
 1967
PENTAZOCINE
CHEMBL100116
 1967
DIPHENOXYLATE
CHEMBL1201294
 1960
OXYMORPHONE
CHEMBL963
 1959
CODEINE
CHEMBL485
 1952
OXYCODONE
CHEMBL656
 1950
METHADONE
CHEMBL651
 1947
DIHYDROERGOTAMINE MESYLATE
CHEMBL1200517
 1946
HYDROCODONE
CHEMBL1457
 1943
MEPERIDINE
CHEMBL607
 1942
MEPERIDINE HYDROCHLORIDE
CHEMBL1701
 1942
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T14:18:33Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL233