Compound Detail

CHEMBL1200531

ALFENTANIL HYDROCHLORIDE

💊 Approved Drug

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💊 Approved Drug

CCC(=O)N(c1ccccc1)C1(COC)CCN(CCn2nnn(CC)c2=O)CC1.Cl

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1200531
Name	ALFENTANIL HYDROCHLORIDE
Phase	Approved
Structure Type	MOL
InChI Key	AQORHZJDCHLLJN-UHFFFAOYSA-N
Therapeutic	✓ Yes
Parent Compound	CHEMBL634
Active Moiety	CHEMBL634

Known Names

Alfenta Alfentanil hydrochloride Alfentanil hydrochloride cii Alfentanil hydrochloride monohydrate R 39,209 R 39209 R-39,209 R-39209 Rapifen Rapifen conc Rapifen dilute Rapifen intensive care

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

416.5

MW (Da)

1.38

ALogP

HBA

HBD

85.5

PSA (Å²)

0.61

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	1986
Availability	Prescription
Chirality	Achiral

Routes of Administration

Parenteral

Flags

Black Box Warning

USAN Stem	-fentanil
USAN Year	1980

Extended Properties

Molecular Formula	C21H33ClN6O3
MW	452.99
Aromatic Rings	2
Heavy Atoms	30
NP-Likeness	-0.92

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Mu opioid receptor agonist	AGONIST	Mu-type opioid receptor	✓	✓

Indications

Anesthesia

Drug Warnings

Black Box Warning

misuse

Country: United States

Activity Summary

EC50 2 meas. best 6.88

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Opioid receptors; mu & delta CHEMBL2095149	EC50	6.88	6.88	132.0	1
Mu-type opioid receptor CHEMBL233	EC50	6.11	6.11	781.4	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Opioid receptors; mu & delta	EC50	=	132.04	nM	6.88	PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response as...	-
Mu-type opioid receptor	EC50	=	781.41	nM	6.11	PubChem BioAssay. Counterscreen for agonists of heterodimerization of the mu 1 (...	-

Data from ChEMBL 36 via Core Engine