Compound Detail
CHEMBL1457
HYDROCODONE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1457 |
| Name | HYDROCODONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | LLPOLZWFYMWNKH-CMKMFDCUSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL398707 |
3
Targets
5
Activities
3
Assay Types
0
PK Parameters
20
Publications
5
Known Names
12
Indications
Molecular Properties
299.4
MW (Da)
1.93
ALogP
4
HBA
0
HBD
38.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1943 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Cough Chronic Pain Low Back Pain Nausea Osteoarthritis Pain Vomiting Eye Diseases Neoplasms Rotator Cuff Injuries Wounds and Injuries Ankle Fractures
ATC Classification
R05DA03
hydrocodone
Level 1: RESPIRATORY SYSTEM
Level 2: COUGH AND COLD PREPARATIONS
Activity Summary
EC50 2 meas. best 4.96
Ki 2 meas. best 8.02
IC50 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL233 | Ki | 8.02 | 8.02 | 9.5 | 1 |
| Kappa-type opioid receptor CHEMBL237 | Ki | 6.58 | 6.58 | 260.0 | 1 |
| Mas-related G-protein coupled receptor member X2 CHEMBL5849 | EC50 | 4.96 | 4.845 | 10964.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | Ki | = | 9.5 | nM | 8.02 | Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells ... | 22439881 |
| Kappa-type opioid receptor | Ki | = | 260.0 | nM | 6.58 | Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO c... | 22439881 |
| Mas-related G-protein coupled receptor member X2 | EC50 | = | 10964.78 | nM | 4.96 | Agonist activity at N-terminal Flag-tagged human MRGPRX2 receptor expressed in t... | 28288109 |
| Mas-related G-protein coupled receptor member X2 | EC50 | = | 18620.87 | nM | 4.73 | Agonist activity at MRGPRX2 (unknown origin) expressed in HTLA cells assessed as... | 28288109 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 4 |
| 31597043 | 10.1021/acs.jmedchem.9b01301 | Solute carrier family 22 member 1 | 4 |
| 28288109 | 10.1038/nchembio.2334 | Mas-related G-protein coupled receptor member X2 | 4 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2A | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Cannabinoid receptor 1 | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2B | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 1A | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 3 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-2 adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | D(1A) dopamine receptor | 2 |
| 17725338 | 10.1021/jm070375w | No relevant target | 2 |
| 22439881 | 10.1021/jm3001086 | Unchecked | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Mu-type opioid receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Histamine H2 receptor | 2 |
| 22931300 | 10.1021/tx300075j | Cytochrome P450 3A4 | 2 |
| 22931300 | 10.1021/tx300075j | Liver microsomes | 2 |
| 6166748 | 10.1021/jm00138a015 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine