Compound Detail
CHEMBL398707
HYDROMORPHONE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL398707 |
| Name | HYDROMORPHONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | WVLOADHCBXTIJK-YNHQPCIGSA-N |
| Therapeutic | ✓ Yes |
3
Targets
6
Activities
3
Assay Types
6
PK Parameters
20
Publications
9
Known Names
16
Indications
Molecular Properties
285.3
MW (Da)
1.63
ALogP
4
HBA
1
HBD
49.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1984 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Pain Anemia, Sickle Cell Cancer Pain Chronic Pain Heroin Dependence Ileus Low Back Pain Mucositis Osteoarthritis, Hip Osteoarthritis, Knee Constipation Kidney Neoplasms Kidney Neoplasms Opioid-Related Disorders Opioid-Related Disorders Wounds and Injuries
ATC Classification
N02AA03
hydromorphone
Level 1: NERVOUS SYSTEM
Level 2: ANALGESICS
Activity Summary
Ki 3 meas. best 9.55
EC50 2 meas. best 8.59
IC50 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL233 | Ki | 9.55 | 9.55 | 0.3 | 1 |
| Mu-type opioid receptor CHEMBL233 | EC50 | 8.59 | 8.59 | 2.6 | 1 |
| Kappa-type opioid receptor CHEMBL237 | Ki | 8.55 | 8.55 | 2.8 | 1 |
| Kappa-type opioid receptor CHEMBL237 | EC50 | 7.96 | 7.96 | 11.0 | 1 |
| Delta-type opioid receptor CHEMBL236 | Ki | 7.42 | 7.42 | 38.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 28.0 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 40.0 | nM | Homo sapiens |
| F | 24.0 | % | Homo sapiens |
| Fu | 0.86 | - | Homo sapiens |
| MRT | 2.6 | hr | Homo sapiens |
| T1/2 | 2.3 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | Ki | = | 0.28 | nM | 9.55 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells a... | 19282177 |
| Mu-type opioid receptor | EC50 | = | 2.6 | nM | 8.59 | Agonist activity at human mu opioid receptor expressed in CHO cells assessed as ... | 19282177 |
| Kappa-type opioid receptor | Ki | = | 2.8 | nM | 8.55 | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO ce... | 19282177 |
| Kappa-type opioid receptor | EC50 | = | 11.0 | nM | 7.96 | Agonist activity at human kappa opioid receptor expressed in CHO cells assessed ... | 19282177 |
| Delta-type opioid receptor | Ki | = | 38.0 | nM | 7.42 | Displacement of [3H]naltrindole from human delta opioid receptor expressed in CH... | 19282177 |
Literature References
Data from ChEMBL 36 via Core Engine